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https://hdl.handle.net/2440/34006
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Type: | Journal article |
Title: | Interleukin-16 in tracheal aspirate fluids of newborn infants |
Author: | Wang, He Oei, J. Lui, K. Henry, Richard L. |
Citation: | Early Human Development, 2002; 67 (1-2):79-86 |
Publisher: | Elsevier |
Issue Date: | 2002 |
ISSN: | 0378-3782 |
School/Discipline: | School of Population Health and Clinical Practice : Public Health |
Statement of Responsibility: | He Wang, Julee Oei, Kei Lui and Richard Henry |
Abstract: | Background: It is currently unknown if interleukin (IL)-16 exists in the lungs of ventilated infants, and because the predominant cells in the airways of infants with CLD are CD4+ macrophages, we hypothesized that IL-16 plays a role as a pro-inflammatory mediator in lung inflammation. Aims: To examine if IL-16, a chemoattractant for CD4+ cells, is detectable in airway secretions of ventilated newborns. Its presence may be associated with lung inflammatory responses. Study design: Cohort cross-sectional study. Subjects: Thirty-four mechanically ventilated newborn infants. Main outcome measures: Tracheal fluid (TF) specimens collected during the first month of life were examined for cell differentials determined from cytospin slides and supernatant was analyzed by ELISA for IL-16. Results: Eighty-three cross-sectional tracheal fluid (TF) specimens were analyzed. Eleven of the 27 preterm but none of the 7 term infants developed chronic lung disease (CLD). IL-16, ranging from 203 to 42,073 pg/ml, was detected in 16 of the 46 specimens obtained from CLD infants, 1 of the 30 specimens from 16 non-CLD preterm and 2 of the 7 specimens from 7 term infants (p<0.001). Leukocyte counts (median 16.6 vs. 2.0×10−9/l, p<0.0001) and percentage neutrophils (median 93% vs. 73%, p<0.001) were higher in IL-16 positive specimens. Conclusion: IL-16 is detectable within the airway secretions of ventilated newborn infants and its presence is associated with a neutrophilic infiltration. Further studies are required to investigate its role in chronic inflammation in CLD. |
Keywords: | IL-16; Premature; Chronic lung disease; Inflammation |
DOI: | 10.1016/S0378-3782(01)00257-2 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/505956/description#description |
Appears in Collections: | Public Health publications |
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