Sequencing the genome from nematode to human: changing methods, changing science

Abstract

The history of science tends to be recounted as a story of progress from early goals and discoveries to a unified outcome, in some sense implicit from the beginning, and often due to technological advances. The sequencing of the human genome is no exception. As a crucial part of the Human Genome Project, the history of genomic sequencing is typically presented as a direct result of the discoveries of the structure of DNA and its coding function, together with practical factors such as the development of techniques which made large-scale sequencing possible. However, the history of sequencing is inevitably a more complicated story, not only about molecular biology, but also about the evolving culture of scientific practice at the end of the 20th century.