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https://hdl.handle.net/2440/34736
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Type: | Journal article |
Title: | Differentiation-dependent expression of 17beta-hydroxysteroid dehydrogenase, type 10, in the rodent testis: effect of aging in Leydig cells |
Author: | Ivell, R. Balvers, M. Anand Ivell, R. Paust, H. McKinnell, C. Sharpe, R. |
Citation: | Endocrinology, 2003; 144(7):3130-3137 |
Publisher: | Endocrine Soc |
Issue Date: | 2003 |
ISSN: | 0013-7227 1945-7170 |
Statement of Responsibility: | Richard Ivell, Marga Balvers, Ravinder J. K. Anand, Hans-Joachim Paust, Chris McKinnell, and Richard Sharpe |
Abstract: | Expression of the new 17β-hydroxysteroid dehydrogenase (HSD), type 10 (17β-HSD-10), formerly known as endoplasmic reticulum-associated amyloid-binding protein, has been investigated in the testes of various mammals under normal and perturbed conditions. Results show that 17β-HSD-10 is a major product of both fetal and adult-type Leydig cells. In the former, protein persists until late in postnatal development; and in the short-day hamster model, it does not disappear when Leydig cells involute. During puberty in the rat, immunohistochemical staining for 17β-HSD-10 in adult-type Leydig cells first becomes evident on d 20, increasing to maximal staining intensity by d 35. In the rat, but not in the mouse or any other species examined, there is also staining in late spermatids. Examination of testes from rats subjected to perinatal treatment with either a GnRH antagonist or low and high doses of diethylstilbestrol revealed that expression of 17β-HSD-10 follows closely Leydig cell differentiation status, correlating with 3β-HSD expression in a previous study. In aging (23 months) rat testes, Leydig cell (but not germ cell) immunostaining for 17β-HSD-10 is markedly reduced. 17β-HSD-10 seems to preferentially convert 3α-androstanediol into dihydrotestosterone, and estradiol to estrone. Thus, perinatal expression of this enzyme in fetal Leydig cells may contribute to protecting these cells from estrogens and encourage androgen formation. |
Rights: | © 2003 by The Endocrine Society |
DOI: | 10.1210/en.2002-0082 |
Published version: | http://dx.doi.org/10.1210/en.2002-0082 |
Appears in Collections: | Aurora harvest 6 Molecular and Biomedical Science publications |
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