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https://hdl.handle.net/2440/34802
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dc.contributor.author | Olayioye, M. | - |
dc.contributor.author | Hoffmann, P. | - |
dc.contributor.author | Pomorski, T. | - |
dc.contributor.author | Armes, J. | - |
dc.contributor.author | Simpson, R. | - |
dc.contributor.author | Kemp, B. | - |
dc.contributor.author | Lindeman, G. | - |
dc.contributor.author | Visvader, J. | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Cancer Research, 2004; 64(10):3538-3544 | - |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.issn | 1538-7445 | - |
dc.identifier.uri | http://hdl.handle.net/2440/34802 | - |
dc.description.abstract | We have identified that StarD10, a member of the START protein family, is overexpressed in both mouse and human breast tumors. StarD10 was initially discovered on the basis of its cross-reactivity with a phosphoserine-specific antibody in mammary tumors from Neu/ErbB2 transgenic mice and subsequently isolated from SKBR3 human breast carcinoma cells using a multistep biochemical purification strategy. We have shown that StarD10 is capable of binding lipids. StarD10 was found to be overexpressed in 35% of primary breast carcinomas and 64% of human breast cancer cell lines, correlating with their ErbB2/Her2 status. Coexpression of StarD10 with ErbB1/epidermal growth factor receptor in murine fibroblasts enhanced anchorage-independent growth in soft agar, providing evidence for functional cooperation between StarD10 and ErbB receptor signaling. Taken together, these data suggest that overexpression of this lipid-binding protein contributes to breast oncogenesis. | - |
dc.description.statementofresponsibility | Monilola A. Olayioye, Peter Hoffmann, Thomas Pomorski, Jane Armes, Richard J. Simpson, Bruce E. Kemp, Geoffrey J. Lindeman, and Jane E. Visvader | - |
dc.language.iso | en | - |
dc.publisher | Amer Assoc Cancer Research | - |
dc.source.uri | http://cancerres.aacrjournals.org/cgi/content/abstract/64/10/3538 | - |
dc.subject | Cell Line, Tumor | - |
dc.subject | Animals | - |
dc.subject | Humans | - |
dc.subject | Mice | - |
dc.subject | Breast Neoplasms | - |
dc.subject | Mammary Neoplasms, Experimental | - |
dc.subject | Cell Transformation, Neoplastic | - |
dc.subject | Receptor, erbB-2 | - |
dc.subject | Phosphoproteins | - |
dc.subject | Transcription Factors | - |
dc.subject | Antibody Specificity | - |
dc.subject | Cross Reactions | - |
dc.subject | Amino Acid Sequence | - |
dc.subject | Sequence Homology, Amino Acid | - |
dc.subject | Molecular Weight | - |
dc.subject | Molecular Sequence Data | - |
dc.subject | Forkhead Transcription Factors | - |
dc.subject | ErbB Receptors | - |
dc.subject | Forkhead Box Protein O1 | - |
dc.title | The Phosphoprotein StarD10 Is Overexpressed in Breast Cancer and Cooperates with ErbB Receptors in Cellular Transformation | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1158/0008-5472.CAN-03-3731 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
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