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https://hdl.handle.net/2440/34813
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Type: | Journal article |
Title: | Genomic organization and expression of the doublesex-related gene cluster in vertebrates and detection of putative regulatory regions for DMRT1 |
Author: | Brunner, Bodo Hornung, Ute Shan, Zhihong Nanda, Indrajit Kondo, Mariko Tsend-Ayush, Enkhjargal Haaf, Thomas Ropers, Hans-Hilger Shima, Akihiro Schmid, Michael Kalscheuer, Vera M. Schartl, Manfred |
Citation: | Genomics, 2001; 77(1-2):8-17 |
Publisher: | Academic Press - Elsevier Science |
Issue Date: | 2001 |
ISSN: | 0888-7543 |
School/Discipline: | School of Molecular and Biomedical Science |
Statement of Responsibility: | Bodo Brunner, Ute Hornung, Zihong Shan, Indrajit Nanda, Mariko Kondo, Enchshargal Zend-Ajusch, Thomas Haaf, Hans-Hilger Ropers, Akihiro Shima, Michael Schmid, Vera M. Kalscheuer and Manfred Schartl |
Abstract: | Genes related to the Drosophila melanogaster doublesex and Caenorhabditis elegans mab-3 genes are conserved in human. They are identified by a DNA-binding homology motif, the DM domain, and constitute a gene family (DMRTs). Unlike the invertebrate genes, whose role in the sex-determination process is essentially understood, the function of the different vertebrate DMRT genes is not as clear. Evidence has accumulated for the involvement of DMRT1 in male sex determination and differentiation. DMRT2 (known as terra in zebrafish) seems to be a critical factor for somitogenesis. To contribute to a better understanding of the function of this important gene family, we have analyzed DMRT1, DMRT2, and DMRT3 from the genome model organism Fugu rubripes and the medakafish, a complementary model organism for genetics and functional studies. We found conservation of synteny of human chromosome 9 in F. rubripes and an identical gene cluster organization of the DMRTs in both fish. Although expression analysis and gene linkage mapping in medaka exclude a function for any of the three genes in the primary step of male sex determination, comparison of F. rubripes and human sequences uncovered three putative regulatory regions that might have a role in more downstream events of sex determination and human XY sex reversal. |
Keywords: | DMRT1; DMRT2; DMRT3; sex determination; medaka; Fugu rubripes; synteny; regulatory elements |
DOI: | 10.1006/geno.2001.6615 |
Appears in Collections: | Molecular and Biomedical Science publications |
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