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https://hdl.handle.net/2440/34823
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Type: | Journal article |
Title: | Species-specific evolution of repeated DNA sequences in great apes |
Author: | Toder, R. Grutzner, F. Haaf, T. Bausch, E. |
Citation: | Chromosome Research: the international journal for all aspects of chromosome and nuclear biology, 2001; 9(6):431-435 |
Publisher: | Kluwer Academic Publ |
Issue Date: | 2001 |
ISSN: | 0967-3849 1573-6849 |
Statement of Responsibility: | R. Toder, F. Grützner, T. Haaf, E. Bausch |
Abstract: | DNA sequencing reveals that the genomes of the human, gorilla and chimpanzee share more than 98% homology. Comparative chromosome painting and gene mapping have demonstrated that only a few rearrangements of a putative ancestral mammalian genome occurred during great ape and human evolution. However, interspecies representational difference analysis (RDA) of the gorilla between human and gorilla revealed gorilla-specific DNA sequences. Cloning and sequencing of gorilla-specific DNA sequences indicate that there are repetitive elements. Gorilla-specific DNA sequences were mapped by fluorescence in-situ hybridization (FISH) to the subcentromeric/centromeric regions of three pairs of gorilla submetacentric chromosomes. These sequences could represent either ancient sequences that got lost in other species, such as human and orang-utan, or, more likely, recent sequences which evolved or originated specifically in the gorilla genome. |
Keywords: | genome evolution - species-specific DNA sequences |
Description: | The original publication can be found at www.springerlink.com |
DOI: | 10.1023/A:1011605824530 |
Published version: | http://dx.doi.org/10.1023/a:1011605824530 |
Appears in Collections: | Aurora harvest Environment Institute Leaders publications Molecular and Biomedical Science publications |
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