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https://hdl.handle.net/2440/34859
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Type: | Journal article |
Title: | The preparation of side chain functionalized analogues of coenzyme Q for protein conjugation studies |
Author: | Daines, A. Abell, A. |
Citation: | Organic and Biomolecular Chemistry, 2004; 2(16):2371-2375 |
Publisher: | Royal Soc Chemistry |
Issue Date: | 2004 |
ISSN: | 1477-0520 1477-0539 |
Abstract: | The synthesis of two analogues of CoQ ( 10 and 13) suitable for conjugation to a peptide or protein, and hence the development of an ELISA immunoassay, is presented. These analogues were synthesized from the protected quinone, 1-bromo-2-methyl-3,4,5,6-tetramethoxybenzene ( 1), itself prepared from commercially available CoQ-0 ( 3). Model coupling studies of one of the analogues ( 10) to N-acetyl-L-lysine methyl ester and a lysine containing dipeptide (N-acetyl-glycine-L-lysine methyl ester) were also undertaken as a first step to monoclonial antibody production. |
Keywords: | Ubiquinone Proteins Molecular Structure Protein Binding |
DOI: | 10.1039/b407659a |
Published version: | http://dx.doi.org/10.1039/b407659a |
Appears in Collections: | Aurora harvest 6 Chemistry publications |
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