Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/35069
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli |
Author: | Diatchenko, L. Nackley Neely, A. Slade, G. Bhalang, K. Shabalina, S. Max, M. Goldman, D. Maixner, W. |
Citation: | Pain, 2006; 125(3):216-224 |
Publisher: | Elsevier Science BV |
Issue Date: | 2006 |
ISSN: | 0304-3959 1872-6623 |
Statement of Responsibility: | Luda Diatchenko, Andrea G. Nackley, Gary D. Slade, Kanokporn Bhalang, Inna Belfer, Mitchell B. Max, David Goldman and William Maixner |
Abstract: | Variations in the gene encoding catechol-O-methyltransferase (COMT) are linked to individual differences in pain sensitivity. A single nucleotide polymorphism (SNP) in codon 158 (val158met), which affects COMT protein stability, has been associated with the human experience of pain. We recently demonstrated that three common COMT haplotypes, which affect the efficiency of COMT translation, are strongly associated with a global measure of pain sensitivity derived from individuals’ responses to noxious thermal, ischemic, and pressure stimuli. Specific haplotypes were associated with low (LPS), average (APS), or high (HPS) pain sensitivity. Although these haplotypes included the val158met SNP, a significant association with val158met variants was not observed. In the present study, we examined the association between COMT genotype and specific pain-evoking stimuli. Threshold and tolerance to thermal, ischemic, and mechanical stimuli, as well as temporal summation to heat pain, were determined. LPS/LPS homozygotes had the least, APS/APS homozygotes had average, and APS/HPS heterozygotes had the greatest pain responsiveness. Associations were strongest for measures of thermal pain. However, the rate of temporal summation of heat pain did not differ between haplotype combinations. In contrast, the val158met genotype was associated with the rate of temporal summation of heat pain, but not with the other pain measures. This suggests that the val158met SNP plays a primary role in variation in temporal summation of pain, but that other SNPs of the COMT haplotype exert a greater influence on resting nociceptive sensitivity. Here, we propose a mechanism whereby these two genetic polymorphisms differentially affect pain perception. |
Keywords: | Catechol-O-methyltransferase (COMT) Pain perception Single nucleotide polymorphism (SNP) Haplotype COMT val158met polymorphism Sensitivity to heat pain Sensitivity to ischemic pain Sensitivity to pressure pain Temporal summation of heat pain Pain sensitivity Windup |
Description: | Copyright © 2006 International Association for the Study of Pain Published by Elsevier B.V |
DOI: | 10.1016/j.pain.2006.05.024 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/506083/description#description |
Published version: | http://dx.doi.org/10.1016/j.pain.2006.05.024 |
Appears in Collections: | Aurora harvest Dentistry publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.