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https://hdl.handle.net/2440/35525
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dc.contributor.author | Fahy, O. | - |
dc.contributor.author | Townley, S. | - |
dc.contributor.author | McColl, S. | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | Infection and Immunity, 2006; 74(12):6885-6894 | - |
dc.identifier.issn | 0019-9567 | - |
dc.identifier.issn | 1098-5522 | - |
dc.identifier.uri | http://hdl.handle.net/2440/35525 | - |
dc.description | Copyright © 2006, American Society for Microbiology | - |
dc.description.abstract | CXCL16 is a recently discovered multifaceted chemokine that has been shown not only to recruit activated T lymphocytes but also to play a direct role in the binding and phagocytosis of bacteria by professional antigen-presenting cells. In this study, we investigated the role of CXCL16 in vivo in the regulation of the immune response using a murine model of Salmonella enterica serovar Enteritidis infection. The expression of CXCL16 was strongly upregulated in the spleens and livers of animals developing an immune response to a primary acute infection but not in the Peyer's patches. Animals developing a secondary response after reexposure to the bacteria displayed a similar pattern of expression. During the primary response, prior treatment with neutralizing antibodies to CXCL16 induced a significant increase in bacterial burden in the spleen and liver. The production of gamma interferon (IFN-γ) by the lymphocytes in the spleen was decreased by anti-CXCL16 treatment. In comparison, during the secondary response, anti-CXCL16 treatment also significantly increased bacterial burden in both the spleen and liver but had no effect on IFN-γ production. No role was found for CXCL16 in the production of antibody against SefA, a major surface antigen of S. enteritidis. Together, these results demonstrate a role for CXCL16 in the control of bacterial colonization of target organs and, more specifically, in the regulation of the cell-mediated arm of the primary response to S. enteritidis. | - |
dc.description.statementofresponsibility | Olivier L. Fahy, Scott L. Townley, and Shaun R. McColl | - |
dc.language.iso | en | - |
dc.publisher | Amer Soc Microbiology | - |
dc.source.uri | http://www.pubmedcentral.nih.gov/articlerender.fcgi?&pubmedid=16982830 | - |
dc.subject | Lymphocytes | - |
dc.subject | Animals | - |
dc.subject | Mice, Inbred BALB C | - |
dc.subject | Mice | - |
dc.subject | Salmonella enteritidis | - |
dc.subject | Salmonella Infections | - |
dc.subject | Chemokines, CXC | - |
dc.subject | Antibodies, Blocking | - |
dc.subject | Up-Regulation | - |
dc.subject | Female | - |
dc.subject | Receptors, Scavenger | - |
dc.subject | Chemokine CXCL10 | - |
dc.subject | Chemokine CXCL9 | - |
dc.subject | Chemokine CXCL11 | - |
dc.subject | Chemokine CXCL6 | - |
dc.subject | Interferon-gamma | - |
dc.subject | Chemokine CXCL16 | - |
dc.title | CXCL16 regulates cell-mediated immunity to Salmonella enterica serovar Enteritidis via promotion of gamma interferon production | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1128/IAI.01065-06 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | McColl, S. [0000-0003-0949-4660] | - |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
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