Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/35562
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Type: | Journal article |
Title: | Continuous positive airway pressure reduces daytime sleepiness in mild to moderate obstructive sleep apnoea: a meta-analysis |
Author: | Marshall, N. Barnes, M. Travier, N. Campbell, A. Pierce, R. McEvoy, R. Neill, A. Gander, P. |
Citation: | Thorax, 2006; 61(5):430-434 |
Publisher: | British Med Journal Publ Group |
Issue Date: | 2006 |
ISSN: | 0040-6376 1468-3296 |
Abstract: | Background: Obstructive sleep apnoea syndrome (OSAS) affects an estimated 2–4% of the middle aged population. Meta-analyses of randomised controlled trials have shown that the severe presentation of the syndrome (apnoea hypopnoea index (AHI) >30/hour) is effectively treated with continuous positive airway pressure (CPAP). Until recently there have been insufficient data to determine whether CPAP improves sleepiness in the larger subgroup with mild to moderate OSAS (AHI 5–30/hour). Methods: A systematic search of Medline and a hand search identified seven randomised controlled trials where CPAP was compared with either a placebo or with conservative management in the treatment of mild to moderate OSAS (AHI 5–30/hour). All trials used the Epworth Sleepiness Scale (ESS), four used the Multiple Sleep Latency Test (MSLT), and three used the Maintenance of Wakefulness Test (MWT) to measure sleepiness. Results: Meta-analyses indicated that CPAP significantly reduced subjective daytime sleepiness (ESS) by 1.2 points (95% CI 0.5 to 1.9, p = 0.001), improved objective daytime wakefulness (MWT) by 2.1 minutes (95% CI 0.5 to 3.7, p = 0.011), but did not affect objective daytime sleepiness (MSLT, mean benefit –0.2 minutes, 95% CI –1.0 to 0.6, p = 0.6). The two significant effects were small (effect size <0.30). Conclusions: CPAP elicits small improvements in subjective sleepiness and objective wakefulness in people with mild to moderate OSAS. However, the effects on sleepiness are of limited clinical significance. |
Keywords: | Humans Sleep Apnea, Obstructive Sleep Initiation and Maintenance Disorders Continuous Positive Airway Pressure Wakefulness Adult Middle Aged Female Male Randomized Controlled Trials as Topic |
DOI: | 10.1136/thx.2005.050583 |
Published version: | http://dx.doi.org/10.1136/thx.2005.050583 |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
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