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https://hdl.handle.net/2440/35564
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DC Field | Value | Language |
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dc.contributor.author | Nalivaiko, E. | - |
dc.contributor.author | Catcheside, P. | - |
dc.contributor.author | Adams, A. | - |
dc.contributor.author | Jordan, A. | - |
dc.contributor.author | Eckert, D. | - |
dc.contributor.author | McEvoy, R. | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 2007; 292(3):R1320-R1327 | - |
dc.identifier.issn | 0363-6119 | - |
dc.identifier.issn | 1522-1490 | - |
dc.identifier.uri | http://hdl.handle.net/2440/35564 | - |
dc.description.abstract | Our aim was to evaluate cardiac changes evoked by spontaneous and sound-induced arousals from sleep. Cardiac responses to spontaneous and auditory-induced arousals were recorded during overnight sleep studies in 28 young healthy subjects (14 males, 14 females) during non-rapid eye movement sleep. Computerized analysis was applied to assess beat-to-beat changes in heart rate, atrio-ventricular conductance, and ventricular repolarization from 30 s before to 60 s after the auditory tone. During both types of arousals, the most consistent change was the increase in the heart rate (in 62% of spontaneous and in 89% of sound-induced arousals). This was accompanied by an increase or no change in PR interval and by a decrease or no change in QT interval. The magnitude of all cardiac changes was significantly higher for tone-induced vs. spontaneous arousals (mean +/- SD for heart rate: +9 +/- 8 vs. +13 +/- 9 beats per min; for PR prolongation: 14 +/- 16 vs. 24 +/- 22 ms; for QT shortening: -12 +/- 6 vs. -20 +/- 9 ms). The prevalence of transient tachycardia and PR prolongation was also significantly higher for tone-induced vs. spontaneous arousals (tachycardia: 85% vs. 57% of arousals, P < 0.001; PR prolongation: 51% vs. 25% of arousals, P < 0.001). All cardiac responses were short-lasting (10-15 s). We conclude that cardiac pacemaker region, conducting system, and ventricular myocardium may be under independent neural control. Prolongation of atrio-ventricular delay may serve to increase ventricular filling during arousal from sleep. Whether prolonged atrio-ventricular conductance associated with increased sympathetic outflow to the ventricular myocardium contributes to arrhythmogenesis during sudden arousal from sleep remains to be evaluated. | - |
dc.language.iso | en | - |
dc.publisher | Amer Physiological Soc | - |
dc.source.uri | http://dx.doi.org/10.1152/ajpregu.00642.2006 | - |
dc.subject | Atrioventricular Node | - |
dc.subject | Humans | - |
dc.subject | Tachycardia | - |
dc.subject | Electrocardiography | - |
dc.subject | Electrooculography | - |
dc.subject | Electromyography | - |
dc.subject | Acoustic Stimulation | - |
dc.subject | Arousal | - |
dc.subject | Sleep | - |
dc.subject | Sleep Stages | - |
dc.subject | Heart Rate | - |
dc.subject | Time Factors | - |
dc.subject | Adult | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.title | Cardiac changes during arousals from non-REM sleep in healthy volunteers | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1152/ajpregu.00642.2006 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Catcheside, P. [0000-0002-9372-6788] | - |
dc.identifier.orcid | McEvoy, R. [0000-0002-5759-0094] | - |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
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