Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/35679
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Upton, R. | - |
dc.contributor.author | Semple, T. | - |
dc.contributor.author | Macintyre, P. | - |
dc.contributor.author | Foster, D. | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | Acute Pain, 2006; 8(3):109-116 | - |
dc.identifier.issn | 1366-0071 | - |
dc.identifier.uri | http://hdl.handle.net/2440/35679 | - |
dc.description.abstract | Background: The sources of variability in the blood concentrations of morphine after subcutaneous administration are unclear. Methods: A population pharmacokinetic model (using NONMEM) was used to examine data on morphine disposition following its administration (5 mg) via an indwelling s.c. cannula to elderly post-operative patients. Results: A two-compartment model with first order absorption was preferred. The between subject variability (BSV) was between 45 and 95% for the systemic parameters, and 71% for the absorption rate constant. The rate of subcutaneous absorption of morphine was not inherently more variable than other factors affecting morphine disposition. A sensitivity analysis supported these findings. In eight patients who received a second dose of morphine approximately 300 min after the first dose, the between occasion variability (BOV) of the parameters was up to 81% of the total variability. Conclusions: A significant component of the variability in morphine disposition was due to factors that could alter within a patient between doses. Taken together, this reinforces the need to titrate the dose of morphine to clinical endpoints, and questions the concept of a fixed dose for a given patient over time, especially if given at fixed dose intervals (i.e. on a time-contingent basis). © 2006 Elsevier B.V. All rights reserved. | - |
dc.language.iso | en | - |
dc.publisher | Elsevier BV | - |
dc.source.uri | http://dx.doi.org/10.1016/j.acpain.2006.06.002 | - |
dc.title | Population pharmacokinetic modelling of subcutaneous morphine in the elderly | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.acpain.2006.06.002 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Upton, R. [0000-0001-9996-4886] | - |
dc.identifier.orcid | Macintyre, P. [0000-0002-1569-8056] | - |
dc.identifier.orcid | Foster, D. [0000-0002-7345-4084] | - |
Appears in Collections: | Anaesthesia and Intensive Care publications Aurora harvest 6 |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.