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https://hdl.handle.net/2440/35752
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Type: | Journal article |
Title: | A possible role for CCL27/CTACK-CCR10 interaction in recruiting CD4+ T cells to skin in human graft-versus-host disease |
Author: | Faaij, C. Lankester, A. Spierings, E. Hoogeboom, M. Bowman, E. Bierings, M. Revesz, T. Egeler, R. van Tol, M. Annels, N. |
Citation: | British Journal of Haematology, 2006; 133(5):538-549 |
Publisher: | Blackwell Publishing Ltd |
Issue Date: | 2006 |
ISSN: | 0007-1048 1365-2141 |
Statement of Responsibility: | Faaij, Claudia M. J. M. ; Lankester, Arjan C. ; Spierings, Eric ; Hoogeboom, Manja ; Bowman, Edward P. ; Bierings, Marc ; Révész, Tom ; Egeler, R. Maarten ; Van Tol, Maarten J. D. ; Annels, Nicola E |
Abstract: | Graft-versus-host disease (GvHD) is a serious complication of allogeneic stem cell transplantation (SCT) affecting the skin, gut and liver. The involvement of distinct organs suggests a role for tissue-specific chemokines and their receptors in directing activated donor T cells to these sites. In this study the potential involvement of the skin-specific CCL27/CTACK-CCR10 interaction was investigated in 15 paediatric SCT patients with skin GvHD. During the course of skin GvHD, peripheral blood T cells from these patients contained a high proportion of CD4+ CCR10+ T cells that disappeared after the GvHD was resolved. These cells were CD45RO+, expressed additional skin homing markers (cutaneous lymphocyte-associated antigen and CCR4), and produced the T-cell helper type 1-cytokines tumour necrosis factor-alpha and interleukin-2. The increase in CD4+ CCR10+ T cells was absent in SCT patients without GvHD. Immunohistochemical investigations showed CD4+ CCR10+ T cells in the GvHD skin biopsies of the same patients, but not in the gut biopsies of patients also suffering from gut GvHD. The infiltration of CD4+ CCR10+ T cells in the GvHD-affected skin correlated with an enhanced epidermal expression of CCL27/CTACK, the ligand for CCR10. These findings support the involvement of CCL27/CTACK-CCR10 interaction in recruiting CD4+ T cells to the skin, thus contributing to the pathogenesis of acute GvHD. |
Keywords: | Human T Cells Graft‐‐host Disease Chemokines Cell Trafficking |
DOI: | 10.1111/j.1365-2141.2006.06058.x |
Published version: | http://dx.doi.org/10.1111/j.1365-2141.2006.06058.x |
Appears in Collections: | Aurora harvest 6 Paediatrics publications |
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