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https://hdl.handle.net/2440/38706
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Type: | Journal article |
Title: | Growth hormone induces bone morphogenetic proteins and bone-related proteins in the developing rat periodontium |
Author: | Li, H. Bartold, P. Young, W. Xiao, Y. Waters, M. |
Citation: | Journal of Bone and Mineral Research, 2001; 16(6):1068-1076 |
Publisher: | Amer Soc Bone & Mineral Res |
Issue Date: | 2001 |
ISSN: | 0884-0431 1523-4681 |
Statement of Responsibility: | Huika Li, P. Mark Bartold, William G. Young, Yin Xiao and Michael J. Waters |
Abstract: | The hypothesis that growth hormone (GH) up-regulates the expression of enzymes, matrix proteins, and differentiation markers involved in mineralization of tooth and bone matrices was tested by the treatment of Lewis dwarf rats with GH over 5 days. The molar teeth and associated alveolar bone were processed for immunohistochemical demonstration of bone morphogenetic proteins 2 and 4 (BMP-2 and -4), bone morphogenetic protein type IA receptor (BMPR-IA), bone alkaline phosphatase (ALP), osteocalcin (OC), osteopontin (OPN), bone sialoprotein (BSP), and E11 protein (E11). The cementoblasts, osteoblasts, and periodontal ligament (PDL) cells responded to GH by expressing BMP-2 and -4, BMPR-IA, ALP, OC, and OPN and increasing the numbers of these cells. No changes were found in patterns of expression of the late differentiation markers BSP and E11 in response to GH. Thus, GH evokes expression of bone markers of early differentiation in cementoblasts, PDL cells, and osteoblasts of the periodontium. We propose that the induction of BMP-2 and -4 and their receptor by GH compliments the role of GH-induced insulin-like growth factor 1 (IGF-1) in promoting bone and tooth root formation. |
Keywords: | Extracellular Matrix Periodontium Molar Animals Rats, Inbred Lew Rats Growth Hormone Alkaline Phosphatase Sialoglycoproteins Osteocalcin Bone Morphogenetic Proteins Receptors, Growth Factor Male Bone Morphogenetic Protein Receptors, Type I Osteopontin Integrin-Binding Sialoprotein Biomarkers Protein Serine-Threonine Kinases |
Rights: | Copyright © 2001 by the American Society for Bone and Mineral Research |
DOI: | 10.1359/jbmr.2001.16.6.1068 |
Published version: | http://dx.doi.org/10.1359/jbmr.2001.16.6.1068 |
Appears in Collections: | Aurora harvest Dentistry publications |
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