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https://hdl.handle.net/2440/43633
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Type: | Journal article |
Title: | Antimicrobial compounds from Eremophila serrulata |
Author: | Ndi, C. Semple, S. Griesser, H. Pyke, S. Barton, M. |
Citation: | Phytochemistry: the international journal of plant chemistry, plant biochemistry and molecular biology, 2007; 68(21):2684-2690 |
Publisher: | Pergamon-Elsevier Science Ltd |
Issue Date: | 2007 |
ISSN: | 0031-9422 1873-3700 |
Statement of Responsibility: | Chi P. Ndi, Susan J. Semple, Hans J. Griesser, Simon M. Pyke and Mary D. Barton |
Abstract: | We report a search for antimicrobial compounds in the Australian plant Eremophila serrulata. Bioassay directed fractionation of a diethyl ether extract prepared from the leaves of E. serrulata led to the isolation of two compounds, an ο-naphthoquinone, 9-methyl-3-(4-methyl-3-pentenyl)-2,3-dihydronaphtho[1,8-bc]pyran-7,8-dione (2), and a serrulatane diterpenoid, 20-acetoxy-8-hydroxyserrulat-14-en-19-oic acid (3). Two other known serrulatane-type diterpenoids, 8,20-dihydroxyserrulat-14-en-19-oic acid (4) and 8,20-diacetoxyserrulat-14-en-19-oic acid (5) were also isolated. None of these compounds had previously been tested for antimicrobial activity. Compounds 2–5 showed antimicrobial activity against Staphylococcus aureus (ATCC 29213) with minimum inhibitory concentrations (MICs) ranging from 15.6 to 250 μg/mL. Compound 2 was the most active with an MIC of 15.6 μg/mL and a minimum bactericidal concentration (MBC) of 125 μg/mL. This compound also showed antimicrobial activity against other Gram-positive bacteria including Streptococcus pyogenes, and Streptococcus pneumoniae. No activity was observed for this compound against all Gram-negative bacteria tested. |
Keywords: | Staphylococcus aureus Streptococcus pyogenes Eremophila Plant Plant Leaves Diterpenes Pyrones Naphthalenes Plant Preparations Anti-Infective Agents Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Molecular Structure |
Description: | Copyright © 2007 Elsevier Ltd All rights reserved. |
DOI: | 10.1016/j.phytochem.2007.05.039 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/273/description#description |
Published version: | http://dx.doi.org/10.1016/j.phytochem.2007.05.039 |
Appears in Collections: | Aurora harvest Chemistry publications |
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