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https://hdl.handle.net/2440/45252
Type: | Journal article |
Title: | Oral and parenteral immunization with synthetic retro-inverso peptides induce antibodies that cross-react with native peptides and parent antigens |
Author: | Fischer, Peter Comis, Alfio Tyler, Margaret Howden, Merlin |
Citation: | Indian Journal of Biochemistry and Biophysics, 2007; 44 (3):140-144 |
Publisher: | National Institute of Science Communication and Information Resources, CSIR |
Issue Date: | 2007 |
ISSN: | 0301-1208 |
School/Discipline: | School of Molecular and Biomedical Science |
Statement of Responsibility: | Peter Fischer, Alfio Comis, Margaret Tyler and Merlin Howden |
Abstract: | The objective of this study was to determine whether certain retro-inverso peptides have the potential to act as synthetic vaccines in mice, when immunized by injection or orally. Immunization of mice parenterally with conjugates of three such retro-inverso peptides and orally with the unconjugated peptides elicited generally high titres of anti-peptide antibodies. Antibodies against the same three peptides cross-reacted by binding strongly in ELISA to the native peptides and vice versa, regardless of the mode of immunization. Antibodies against a retro-inverso diphtheria peptide also reacted strongly with diphtheria toxin. Seven of 8 mice, immunized by injection of the conjugate of a retro-inverso derivative of robustoxin [a lethal spider (Atrax robustus) venom toxin] were protected from challenge involving injection with twice the minimum lethal dose of A. robustus venom containing the toxin. |
Description (link): | http://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb2k7/ijbb_june07.asp#a2 |
Appears in Collections: | Molecular and Biomedical Science publications |
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