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https://hdl.handle.net/2440/45285
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dc.contributor.author | Roy, P. | - |
dc.contributor.author | Lockington, R. | - |
dc.contributor.author | Kelly, J. | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Fungal Genetics and Biology, 2008; 45(5):657-670 | - |
dc.identifier.issn | 1087-1845 | - |
dc.identifier.issn | 1096-0937 | - |
dc.identifier.uri | http://hdl.handle.net/2440/45285 | - |
dc.description | Copyright © 2007 Elsevier Inc. All rights reserved. | - |
dc.description.abstract | The major regulatory protein in carbon repression in Aspergillus nidulans is CreA. Strains constitutively over-expressing creA show normal responses to carbon repression, indicating that auto-regulation of creA is not essential for CreA-mediated regulation. In these strains, high levels of CreA are present whether cells are grown in repressing or derepressing conditions, indicating large-scale degradation of CreA does not play a key role. CreA is located in the nucleus and cytoplasm in cells when grown in either repressing or derepressing conditions, and absence of CreB, CreD or AcrB does not affect either the localisation or amount of CreA. Therefore, CreA must require some modification or interaction to act as a repressor. Deletion analysis indicates that a region of CreA thought to be important for repression in Trichoderma reesei and Sclerotina sclerotiorum CreA homologues is not critical for function in Aspergillus nidulans. | - |
dc.description.statementofresponsibility | Preeti Roy, Robin A. Lockington and Joan M. Kelly | - |
dc.description.uri | http://www.elsevier.com/wps/find/journaldescription.cws_home/622835/description#description | - |
dc.language.iso | en | - |
dc.publisher | Academic Press Inc Elsevier Science | - |
dc.source.uri | http://dx.doi.org/10.1016/j.fgb.2007.10.016 | - |
dc.subject | Cell Nucleus | - |
dc.subject | Cytoplasm | - |
dc.subject | Ascomycota | - |
dc.subject | Aspergillus nidulans | - |
dc.subject | Trichoderma | - |
dc.subject | Carbon | - |
dc.subject | Fungal Proteins | - |
dc.subject | Green Fluorescent Proteins | - |
dc.subject | Recombinant Fusion Proteins | - |
dc.subject | Repressor Proteins | - |
dc.subject | Microscopy, Fluorescence | - |
dc.subject | Blotting, Western | - |
dc.subject | DNA Mutational Analysis | - |
dc.subject | Gene Expression Regulation, Fungal | - |
dc.subject | Gene Deletion | - |
dc.subject | Mutation | - |
dc.subject | Genes, Reporter | - |
dc.title | CreA-mediated repression in Aspergillus nidulans does not require transcriptional auto-regulation, regulated intracellular localisation or degradation of CreA | - |
dc.type | Journal article | - |
dc.provenance | Available online 1 November 2007. | - |
dc.identifier.doi | 10.1016/j.fgb.2007.10.016 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
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