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https://hdl.handle.net/2440/45382
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Type: | Journal article |
Title: | cis-Urocanic acid stimulates neuropeptide release from peripheral sensory nerves |
Author: | Kahlil, Z. Townley, S. Grimbaldeston, M. Finlay-Jones, J. Hart, P. |
Citation: | Journal of Investigative Dermatology, 2001; 117(4):886-891 |
Publisher: | Blackwell Publishing Inc |
Issue Date: | 2001 |
ISSN: | 0022-202X 1523-1747 |
Statement of Responsibility: | Zeinab Khalil, Scott L Townley, Michele A Grimbaldeston, John J Finlay-Jones and Prue H Hart |
Abstract: | Previous studies using an antibody to cis-urocanic acid and mast-cell-depleted mice implicated both cis-urocanic acid and mast cells in the mechanisms by which ultraviolet B light suppresses systemic contact hypersensitivity responses in mice. In the absence of a direct stimulatory effect of cis-urocanic acid on connective tissue mast cells, an indirect association was investigated. A blister induced in the rat hind footpad was used to examine the effects of slowly perfused cis-urocanic acid on cutaneous blood flow. cis-Urocanic acid but not trans-urocanic acid increased microvascular flow by a mechanism largely dependent on the combined activity of the neuropeptides, substance P and calcitonin gene-related peptide. Perfusion of cis-urocanic acid over the base of blisters induced in sensory-neuropeptide-depleted rats did not have any stimulatory effect above that seen with perfusion of cis-urocanic acid together with neuropeptide receptor antagonists in control rats. There was a small direct effect of cis-urocanic acid on microvascular blood flow. As both substance P and calcitonin gene-related peptide could directly degranulate connective tissue mast cells, this study suggests that cis-urocanic acid indirectly activates mast cells via its effects on peripheral terminals of unmyelinated primary afferent sensory nerves. cis-Urocanic-acid-induced neuropeptides may also contribute to ultraviolet-B-induced cutaneous inflammation and alterations to Langerhans cell activity. |
Keywords: | histamine mast cells rodent skin |
Description: | Copyright © 2001 by the Society of Investigative Dermatology, Inc. |
DOI: | 10.1046/j.0022-202x.2001.01466.x |
Published version: | http://dx.doi.org/10.1046/j.0022-202x.2001.01466.x |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
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