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https://hdl.handle.net/2440/47137
Type: | Journal article |
Title: | Cost-effectiveness of extended adjuvant letrozole therapy after 5 years of adjuvant tamoxifen therapy in postmenopausal women with early-stage breast cancer |
Author: | Delea, T. Karnon, J. Smith, R. Johnston, S. Brandman, J. Sung, J. Goss, P. |
Citation: | American Journal of Managed Care, 2006; 12(7):374-386 |
Publisher: | Amer Med Publishing |
Issue Date: | 2006 |
ISSN: | 1096-1860 1088-0224 |
Statement of Responsibility: | Delea, Thomas E.; Karnon, Jonathan; Smith, Robert E.; Johnston, Stephen R.D.; Brandman, Jane; Sung, Jennifer C.Y.; Goss, Paul E. |
Abstract: | Background: MA17 was a randomised placebo-controlled trial of letrozole 2.5 mg/day in 5187 estrogen receptor-positive, 50% node-negative, postmenopausal women (median age 62 years at enrolment) with early breast cancer, post-5 years Methods: A Markov model was used to estimate the incremental cost per QALY gained with extended adjuvant letrozole versus no therapy. Probabilities of disease progression and death were estimated using data from the MA17 study and other secondary sources. Costs of breast cancer care (letrozole therapy, surveillance, recurrences, terminal care) and treatment of osteoporosis and utilities were derived from literature. A full probabilistic sensitivity analysis was undertaken. The analysis was conducted from the perspective of the UK National Health Service (NHS) and cost estimates reflect 2004 values. All costs and outcomes were discounted at 3.5%. Results: Extended adjuvant letrozole resulted in a gain of 0.36 QALYs per patient (13.66 vs 13.30 with no therapy). These benefits were obtained at an additional expected lifetime cost of Lstg 3732 per patient (Lstg 10 Conclusion: Five years of letrozole therapy appears to be cost effective from the NHS perspective and should be considered in women with early breast cancer, following tamoxifen adjuvant therapy. |
Keywords: | Humans Breast Neoplasms Neoplasm Metastasis Neoplasm Recurrence, Local Disease Progression Tamoxifen Nitriles Triazoles Antineoplastic Agents, Hormonal Antineoplastic Combined Chemotherapy Protocols Aromatase Inhibitors Neoplasm Staging Chemotherapy, Adjuvant Markov Chains Cohort Studies Age Factors Postmenopause Decision Support Techniques Quality-Adjusted Life Years Time Factors Adult Aged Aged, 80 and over Middle Aged Cost-Benefit Analysis United States Female Letrozole |
Rights: | Copyright © 2004 American Society of Clinical Oncology |
Appears in Collections: | Aurora harvest 6 Public Health publications |
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