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https://hdl.handle.net/2440/49505
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Type: | Journal article |
Title: | Immunogenicity of a reduced dose of A/H3N2 in the 2005 southern hemisphere formulation of inactivated split influenza vaccine. |
Author: | Burrell, C. Booy, R. Wood, N. Egan, A. Taverner, D. Williams, K. Liauw, W. Moskwa, A. Pepin-Covatta, S. Saville, M. |
Citation: | Influenza and Other Respiratory Viruses, 2008; 2(3):93-98 |
Publisher: | Wiley-Blackwell Publishing Ltd. |
Issue Date: | 2008 |
ISSN: | 1750-2640 1750-2659 |
Statement of Responsibility: | Christopher Burrell, Robert Booy, Nicholas Wood, Anne-Marie Egan, David Taverner, Ken Williams, Winston Liauw, Alan Moskwa, Stephanie Pepin-Covatta and Melanie Saville |
Abstract: | Background The 2005 southern hemisphere formulation of the inactivated split-virion influenza vaccine Vaxigrip® unintentionally contained a lower concentration of haemagglutinin (HA) than European Pharmacopoeia (EP) and WHO specifications for one of the three strains. Objectives To evaluate the immunogenicity of the 2005 southern hemisphere formulation of an influenza vaccine containing 9 μg/dose of HA for A/Wellington/1/2004(H3N2) strain, and 15 μg/dose for each of the A/New Caledonia/20/99(H1N1) strain and B/Shanghai/361/2002-like strains. Patients/methods In an open, non-controlled multicentre clinical trial, 75 healthy adults (18–59 years) and 65 healthy older adults (≥60 years) were vaccinated once. Serum samples were obtained on D0 and 21 for haemagglutination inhibition (HAI) antibody titration. Results A high proportion of adults (64%) and elderly (68%) were already seroprotected (HAI titre of ≥40) against A/Wellington/1/2004(H3N2) before vaccination, probably due to high circulation of an antigenically similar H3N2 strain and a high 2004 vaccination rate. By D21, seroprotection rates against H3N2 attained 93·8% and 96·0% in adults and elderly respectively. The other two immunogenicity criteria for annual licensure of influenza vaccines in Europe were also met in both age groups for the H3N2 strain, and also for the H1N1 and B strains. Conclusions These results enabled the 2005 southern hemisphere vaccine to be used in expectation that it would provide satisfactory protection against influenza, despite the reduced H3N2 antigen content. |
Keywords: | Humans Influenza B virus Vaccines, Inactivated Vaccines, Subunit Influenza Vaccines Antibodies, Viral Hemagglutination Inhibition Tests Drug Approval Adolescent Adult Aged Aged, 80 and over Middle Aged Female Male Influenza A Virus, H3N2 Subtype Influenza A Virus, H1N1 Subtype Young Adult |
Rights: | © 2008 The Authors. Journal Compilation © 2008 Blackwell Publishing Ltd |
DOI: | 10.1111/j.1750-2659.2008.00039.x |
Published version: | http://dx.doi.org/10.1111/j.1750-2659.2008.00039.x |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
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