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https://hdl.handle.net/2440/51056
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Type: | Journal article |
Title: | Higher dose of docosahexaenoic acid in the neonatal period improves visual acuity of preterm infants: results of a randomized controlled trial |
Author: | Smithers, L. Gibson, R. McPhee, A. Makrides, M. |
Citation: | American Journal of Clinical Nutrition, 2008; 88(4):1049-1056 |
Publisher: | Amer Soc Clinical Nutrition |
Issue Date: | 2008 |
ISSN: | 0002-9165 1938-3207 |
Statement of Responsibility: | Lisa G Smithers, Robert A Gibson, Andrew McPhee, and Maria Makrides |
Abstract: | <h4>Background</h4>Preterm infants have improved visual outcomes when fed a formula containing 0.2-0.4% docosahexaenoic acid (DHA) compared with infants fed no DHA, but the optimal DHA dose is unknown.<h4>Objective</h4>We assessed visual responses of preterm infants fed human milk (HM) and formula with a DHA concentration estimated to match the intrauterine accretion rate (high-DHA group) compared with infants fed HM and formula containing DHA at current concentrations.<h4>Design</h4>A double-blind randomized controlled trial studied preterm infants born at <33 wk gestation and fed HM or formula containing 1% DHA (high-DHA group) or approximately 0.3% DHA (current practice; control group) until reaching their estimated due date (EDD). Both groups received the same concentration of arachidonic acid. Sweep visual evoked potential (VEP) acuity and latency were assessed at 2 and 4 mo corrected age (CA). Weight, length, and head circumference were assessed at EDD and at 2 and 4 mo CA.<h4>Results</h4>At 2 mo CA, acuity of the high-DHA group did not differ from the control group [high-DHA group (x +/- SD): 5.6 +/- 2.4 cycles per degree (cpd), n = 54; control group: 5.6 +/- 2.4 cpd, n = 61; P = 0.96]. By 4 mo CA, the high-DHA group exhibited an acuity that was 1.4 cpd higher than the control group (high-DHA: 9.6 +/- 3.7 cpd, n = 44; control: 8.2 +/- 1.8 cpd; n = 51; P = 0.025). VEP latencies and anthropometric measurements were not different between the high-DHA and control groups.<h4>Conclusion</h4>The DHA requirement of preterm infants may be higher than currently provided by preterm formula or HM of Australian women. |
Keywords: | Milk, Human Humans Body Weight Birth Weight Docosahexaenoic Acids Body Height Double-Blind Method Nutritional Requirements Evoked Potentials, Visual Visual Acuity Dose-Response Relationship, Drug Infant Formula Infant, Newborn Infant, Premature Female Male Infant Nutritional Physiological Phenomena |
Description: | © 2008 American Society for Nutrition |
DOI: | 10.1093/ajcn/88.4.1049 |
Grant ID: | NHMRC |
Published version: | http://dx.doi.org/10.1093/ajcn/88.4.1049 |
Appears in Collections: | Aurora harvest Paediatrics publications |
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