Adelaide Research & Scholarship
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https://hdl.handle.net/2440/51191
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| Type: | Journal article |
| Title: | Synthesis, antifungal, haemolytic and cytotoxic activities of a series of bis(alkylpyridinium)alkanes |
| Author: | Obando, D. Pantarat, N. Handke, R. Koda, Y. Widmer, F. Djordjevic, J. Ellis, D. Sorrell, T. Jolliffe, K. |
| Citation: | Bioorganic and Medicinal Chemistry, 2009; 17(17):6329-6339 |
| Publisher: | Pergamon-Elsevier Science Ltd |
| Issue Date: | 2009 |
| ISSN: | 0968-0896 1464-3391 |
| Statement of Responsibility: | Daniel Obando, Namfon Pantarat, Rosemary Handke, Yasuko Koda, Fred Widmer, Julianne T. Djordjevic, David H. Ellis, Tania C. Sorrell and Katrina A. Jolliffe |
| Abstract: | A series of bis(alkylpyridinium)alkanes with a twelve carbon spacer between the positive charges was synthesised and their antifungal activity has been investigated. Compounds with 2-pentyl, 4-pentyl, 4-hexyl, 4-octyl, 4-propylbenzene, 3,4-dipentyl, 4-(5′-nonyl) and 3-methyl,4-pentyl head groups were the most potent antifungal agents with MICs in the range of 1.4–2.7 μM against reference strains of both Cryptococcus neoformans and Candida albicans. |
| Keywords: | Bispyridinium Antifungal activity Haemolytic activity Fungal phospholipase B |
| Description: | Available online 23 July 2009. |
| Rights: | Copyright © 2009 Elsevier Ltd. All rights reserved |
| DOI: | 10.1016/j.bmc.2009.07.037 |
| Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/129/description#description |
| Published version: | http://dx.doi.org/10.1016/j.bmc.2009.07.037 |
| Appears in Collections: | Aurora harvest 5 Molecular and Biomedical Science publications |
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