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https://hdl.handle.net/2440/51503
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Type: | Journal article |
Title: | Effect of itopride on gastric emptying in longstanding diabetes mellitus |
Author: | Stevens, J. Russo, A. Maddox, A. Rayner, C. Phillips, L. Talley, N. Giguere, M. Horowitz, M. Jones, K. |
Citation: | Neurogastroenterology and Motility, 2008; 20(5):456-463 |
Publisher: | Blackwell Publishing Ltd |
Issue Date: | 2008 |
ISSN: | 1350-1925 1365-2982 |
Statement of Responsibility: | J. E. Stevens, A. Russo, A. F. Maddox, C. K. Rayner, L. Phillips, N. J. Talley, M. Giguère, M. Horowitz & K. L. Jones |
Abstract: | Delayed gastric emptying (GE) occurs in 30–50% of patients with longstanding type 1 or 2 diabetes, and represents a major cause of morbidity. Current therapeutic options are limited. We aimed at evaluating the effects of itopride on GE in patients with longstanding diabetes. Twenty-five patients (20 type 1, 5 type 2; 10 males, 15 females; mean age 45.2 ± 2.7 years; body mass index 27.5 ± 0.9 kg m−2; duration of diabetes 20.2 ± 2.4 years) were enrolled in a double-blind, placebo-controlled, randomized, crossover trial. Subjects received both itopride (200 mg) and placebo t.i.d. for 7 days, with a washout of 7–14 days. GE (scintigraphy), blood glucose (glucometer) and upper gastrointestinal (GI) symptoms (questionnaire) were measured following each treatment period. The test meal comprised 100 g ground beef (99mTc-sulphur colloid) and 150 mL of 10% dextrose [67Ga-ethylenediaminetetraacetic acid (EDTA)]. There was a slight trend for itopride to accelerate both solid (P = 0.09) and liquid (P = 0.09) GE. With itopride treatment, the emptying of both solids and liquids tended to be more accelerated, as the emptying with placebo was slower (solids: r = 0.39, P = 0.057; liquids: r = 0.44, P < 0.03). Twelve (48%) patients had delayed solid and/or liquid GE on placebo and in this group, itopride modestly accelerated liquid (P < 0.05), but not solid (P = 0.39), emptying. Itopride had no effect on mean blood glucose during the GE measurement (placebo: 9.8 ± 0.6 mmol L−1vs itopride: 9.6 ±0.6 mmol L−1), or GI symptoms (placebo: 1.4 ± 0.4 vs itopride: 1.8 ± 0.5). Itopride, in a dose of 200 mg t.i.d. for 7 days, tends to accelerate GE of liquids and solids in longstanding diabetes. The magnitude of this effect appears to be modest and possibly dependent on the rate of GE without itopride. |
Keywords: | diabetes gastric emptying itopride |
Description: | Article first published online: 7 JAN 2008 |
Rights: | © 2008 The Authors. Journal compilation © 2008 Blackwell Publishing Ltd |
DOI: | 10.1111/j.1365-2982.2007.01058.x |
Published version: | http://dx.doi.org/10.1111/j.1365-2982.2007.01058.x |
Appears in Collections: | Aurora harvest Medicine publications |
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