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https://hdl.handle.net/2440/52305
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dc.contributor.author | Yu, C. | - |
dc.contributor.author | Moghaddami, M. | - |
dc.contributor.author | Mayrhofer, G. | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Immunology, 2008; 125(4):558-569 | - |
dc.identifier.issn | 0019-2805 | - |
dc.identifier.issn | 1365-2567 | - |
dc.identifier.uri | http://hdl.handle.net/2440/52305 | - |
dc.description.abstract | Fas-associated protein with death domain/mediator of receptor induced toxicity (FADD/MORT1) was first described as a transducer of death receptor signalling but was later recognized also to be important for proliferation of T cells. B-cell lymphoma 3 (Bcl-3) is a relatively little understood member of the nuclear factor (NF)-kappaB family of transcription factors. We recently found that Bcl-3 is up-regulated in T cells from mice where FADD function is blocked by a dominant negative transgene (FADD-DN). To understand the importance of this, we generated FADD-DN/bcl-3(-/-) mice. Here, we report that T cells from these mice show massive cell death and severely reduced proliferation in response to T-cell receptor (TCR) stimulation in vitro. Transgenic coexpression of Bcl-2 (FADD-DN/bcl-3(-/-)/vav-bcl-2 mice) rescued the survival but not the proliferation of T cells. FADD-DN/bcl-3(-/-) mice had normal thymocyte numbers but reduced numbers of peripheral T cells despite an increase in cycling T cells in vivo. However, activation of the classical NF-kappaB and extracellular regulated kinase (ERK) pathways and expression of interleukin (IL)-2 mRNA upon stimulation were normal in T cells from FADD-DN/bcl-3(-/-) mice. These data suggest that FADD and Bcl-3 regulate separate pathways that both contribute to survival and proliferation in mouse T cells. | - |
dc.description.statementofresponsibility | Chunping Yu, Mahin Moghaddami and Graham Mayrhofer | - |
dc.language.iso | en | - |
dc.publisher | Blackwell Publishing Ltd | - |
dc.source.uri | http://dx.doi.org/10.1111/j.1365-2567.2008.02930.x | - |
dc.subject | Alcian blue | - |
dc.subject | arthritis | - |
dc.subject | connective tissue | - |
dc.subject | rat | - |
dc.subject | Safranin O | - |
dc.subject | serosal | - |
dc.title | Expression of a B-cell-restricted isoform of CD45 is associated with maturity in rat serosal and connective-tissue mast cells | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/j.1365-2567.2008.02930.x | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest Microbiology and Immunology publications |
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