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https://hdl.handle.net/2440/54730
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Type: | Journal article |
Title: | Growth factor based therapies and intestinal disease: Is glucagon-like peptide-2 the new way forward? |
Author: | Yazbek, R. Howarth, G. Abbott, C. |
Citation: | Cytokine and Growth Factor Reviews, 2009; 20(2):175-184 |
Publisher: | Elsevier Sci Ltd |
Issue Date: | 2009 |
ISSN: | 1359-6101 1879-0305 |
Statement of Responsibility: | Roger Yazbeck, Gordon S. Howarth and Catherine A. Abbott |
Abstract: | Inflammatory bowel disease (IBD) is a chronic, debilitating disease associated with severe damage to the intestinal mucosa. Glucagon-like peptide-2 (GLP-2) is a potent and specific gastrointestinal growth factor that is demonstrating therapeutic potential for the prevention or treatment of an expanding number of intestinal diseases, including short bowel syndrome (SBS), small bowel enteritis and IBD. The biological activity of GLP-2 is limited due to proteolytic inactivation by the protease dipeptidyl peptidase (DP)IV. Inhibitors of DPIV activity may represent a novel strategy to prolong the growth promoting actions of GLP-2. This review outlines evidence for the clinical application of GLP-2, its degradation resistant analogue, Teduglutide, and novel DPIV inhibitors in efficacy studies utilizing pre-clinical models of intestinal damage, in particular IBD. |
Keywords: | Animals Humans Neoplasms Inflammatory Bowel Diseases Intestinal Diseases Short Bowel Syndrome Peptides Glucagon-Like Peptide 2 Dipeptidyl-Peptidase IV Inhibitors Dipeptidyl Peptidase 4 |
Description: | Copyright © 2009 Published by Elsevier Ltd. |
DOI: | 10.1016/j.cytogfr.2009.02.008 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/868/description#description |
Published version: | http://dx.doi.org/10.1016/j.cytogfr.2009.02.008 |
Appears in Collections: | Agriculture, Food and Wine publications Aurora harvest 5 |
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