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https://hdl.handle.net/2440/54734
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dc.contributor.author | Ahmad, S. | - |
dc.contributor.author | Esmaeli, B. | - |
dc.contributor.author | Williams, M. | - |
dc.contributor.author | Nguyen, J. | - |
dc.contributor.author | Fay, A. | - |
dc.contributor.author | Woog, J. | - |
dc.contributor.author | Selvadurai, D. | - |
dc.contributor.author | Rootman, J. | - |
dc.contributor.author | Weis, E. | - |
dc.contributor.author | Selva-Nayagam, D. | - |
dc.contributor.author | McNab, A. | - |
dc.contributor.author | De Angelis, D. | - |
dc.contributor.author | Calle, A. | - |
dc.contributor.author | Lopez, A. | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Ophthalmology, 2009; 116(6):1210-1215 | - |
dc.identifier.issn | 0161-6420 | - |
dc.identifier.issn | 1549-4713 | - |
dc.identifier.uri | http://hdl.handle.net/2440/54734 | - |
dc.description | Copyright © 2009 American Academy of Ophthalmology Published by Elsevier Inc. | - |
dc.description.abstract | <h4>Purpose</h4>To investigate whether American Joint Committee on Cancer (AJCC) classification at initial diagnosis of lacrimal gland adenoid cystic carcinoma predicts outcome of treatment on local recurrence.<h4>Design</h4>Retrospective chart review.<h4>Participants</h4>Consecutive patients with adenoid cystic carcinoma of the lacrimal gland treated at 8 institutions between January 1986 and December 2007.<h4>Methods</h4>Clinical records, including pathology reports and imaging studies, were reviewed.<h4>Main outcome measures</h4>AJCC classification, histologic subtype, local recurrence rate, and survival.<h4>Results</h4>AJCC classification at initial diagnosis was assessable for 53 patients and was as follows: T1N0M0, 7 patients; T2N0M0, 8 patients; T3aN0M0, 14 patients; T3aNxM0, 1 patient; T3aN0M1, 1 patient; T3bN0M0, 13 patients; T3bN0M1, 1 patient; T4aN0M0, 2 patients; T4bN0M0, 4 patients; T4bN0M1, 1 patient; and T4bNXM0, 1 patient. Thirty-eight (72%) of the 53 patients had >T3 tumors at presentation. Of the 38 patients with >T3 tumors, 20 were treated with orbital exenteration and postoperative adjuvant radiotherapy (RT), 6 were treated with orbital exenteration without RT, and 12 were treated with globe-preserving surgery (10 with RT and 2 without RT). Of the 15 patients with <T3 tumors, 6 were treated with globe-preserving surgery and RT, 2 were treated with globe-preserving surgery without RT, 6 were treated with orbital exenteration with bone removal and RT, and 1 was treated with orbital exenteration with bone removal without RT. Only 1 patient with a <T3 tumor, had local recurrence. Among patients with >T3 tumors, the risk of local recurrence (in the orbit or skull base) was higher in patients treated with conservative surgery as opposed to orbital exenteration and RT. Only 4 (20%) of the 20 patients treated with orbital exenteration and RT had local recurrence, compared with 3 (50%) of the 6 patients treated with orbital exenteration without RT and 8 (67%) of the 12 patients treated with globe-preserving surgery. Overall, 17 (45%) of the 38 patients with >T3 tumors and only 1 (7%) of the 15 patients with <T3 tumors died of disease during the study period.<h4>Conclusions</h4>In patients with lacrimal gland adenoid cystic carcinoma, AJCC >T3 disease at initial diagnosis correlates with worse outcomes than does AJCC <T3 disease.<h4>Financial disclosure(s)</h4>The author(s) have no proprietary or commercial interest in any materials discussed in this article. | - |
dc.description.statementofresponsibility | S. Mehdi Ahmad, Bita Esmaeli, Michelle Williams, John Nguyen, Aaron Fay, John Wood, Deepan Selvadurai, Jack Rootman, Ezekiel Weis, Dinesh Selva, Alan McNab, Dan DeAngelis, Alberto Calle and Adriana Lopez | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Science Inc | - |
dc.source.uri | http://dx.doi.org/10.1016/j.ophtha.2008.12.049 | - |
dc.subject | Humans | - |
dc.subject | Carcinoma, Adenoid Cystic | - |
dc.subject | Eye Neoplasms | - |
dc.subject | Neoplasm Invasiveness | - |
dc.subject | Neoplasm Recurrence, Local | - |
dc.subject | Lacrimal Apparatus Diseases | - |
dc.subject | Neoplasm Staging | - |
dc.subject | Treatment Outcome | - |
dc.subject | Combined Modality Therapy | - |
dc.subject | Radiotherapy | - |
dc.subject | Ophthalmologic Surgical Procedures | - |
dc.subject | Survival Rate | - |
dc.subject | Retrospective Studies | - |
dc.subject | Adolescent | - |
dc.subject | Adult | - |
dc.subject | Aged | - |
dc.subject | Middle Aged | - |
dc.subject | Child | - |
dc.subject | Societies, Medical | - |
dc.subject | United States | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.title | American Joint Committee on cancer classification predicts outcome of patients with lacrimal gland Adenoid Cystic Carcinoma | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.ophtha.2008.12.049 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Selva-Nayagam, D. [0000-0002-2169-5417] | - |
Appears in Collections: | Aurora harvest 5 Opthalmology & Visual Sciences publications |
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