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https://hdl.handle.net/2440/55384
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Type: | Journal article |
Title: | Herpes simplex virus infection of murine sensory ganglia induces proliferation of neuronal satellite cells |
Author: | Elson, Karen Speck, Peter Gerald Simmons, Anthony |
Citation: | Journal of General Virology, 2003; 84:1079-1084 |
Publisher: | Soc General Microbiology |
Issue Date: | 2003 |
ISSN: | 0022-1317 |
School/Discipline: | School of Medical Sciences : Pathology |
Statement of Responsibility: | Karen Elson, Peter Speck and Anthony Simmons |
Abstract: | Herpes simplex virus (HSV) is a virtually ubiquitous human pathogen that, following cutaneous infection, latently infects neurons of sensory ganglia. Satellite cells (SCs) ensheath and provide metabolic support for these neurons, and could potentially participate in controlling HSV disease. Although SCs are restrictive for HSV replication, hypercellularity of non-neuronal cells in ganglia is prominent during HSV infection in animal models. SCs proliferate in response to trauma, e.g. nerve cut or crush, but it is not known if proliferation occurs in response to viral infection. To address this issue, cell proliferation, measured by bromodeoxyuridine (BrdU) uptake, and immune infiltrate, measured by CD45 labelling, were examined during acute infection in a mouse model. Because SCs do not express CD45, the BrdU⁺ CD45⁻ cell subset represents the proliferating SC population. We report that during acute ganglionic HSV infection there is a substantial increase in SC numbers. We suggest that SC proliferation in response to HSV infection may occur in order to facilitate neuronal survival. |
Description: | © 2003 Society for General Microbiology |
DOI: | 10.1099/vir.0.19035-0 |
Appears in Collections: | Pathology publications |
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