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https://hdl.handle.net/2440/56804
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Type: | Journal article |
Title: | Why do phage play dice? |
Author: | Avlund, M. Dodd, I. Semsey, S. Sneppen, K. Krishna, S. |
Citation: | Journal of Virology, 2009; 83(22):11416-11420 |
Publisher: | Amer Soc Microbiology |
Issue Date: | 2009 |
ISSN: | 0022-538X 1098-5514 |
Statement of Responsibility: | Mikkel Avlund, Ian B. Dodd, Szabolcs Semsey, Kim Sneppen, and Sandeep Krishna |
Abstract: | Phage lambda is among the simplest organisms that make a developmental decision. An infected bacterium goes either into the lytic state, where the phage particles rapidly replicate and eventually lyse the cell, or into a lysogenic state, where the phage goes dormant and replicates along with the cell. Experimental observations by P. Kourilsky are consistent with a single phage infection deterministically choosing lysis and double infection resulting in a stochastic choice. We argue that the phage are playing a "game" of minimizing the chance of extinction and that the shift from determinism to stochasticity is due to a shift from a single-player to a multiplayer game. Crucial to the argument is the clonal identity of the phage. |
Keywords: | Bacteriophage lambda Probability Stochastic Processes Lysogeny Virus Activation Game Theory |
Description: | Copyright © 2009, American Society for Microbiology. All Rights Reserved. |
DOI: | 10.1128/JVI.01057-09 |
Published version: | http://dx.doi.org/10.1128/jvi.01057-09 |
Appears in Collections: | Aurora harvest Biochemistry publications |
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