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https://hdl.handle.net/2440/57780
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Type: | Journal article |
Title: | Population-based surveillance for scedosporiosis in Australia: epidemiology, disease manifestations and emergence of Scedosporium aurantiacum infection |
Author: | Heath, C. Slavin, M. Sorrell, T. Handke, R. Harun, A. Phillips, M. Nguyen, Q. Delhaes, L. Ellis, D. Meyer, W. Chen, S. |
Citation: | Clinical Microbiology and Infection, 2009; 15(7):689-693 |
Publisher: | Blackwell Science Ltd |
Issue Date: | 2009 |
ISSN: | 1198-743X 1469-0691 |
Statement of Responsibility: | C. H. Heath, M. A. Slavin, T. C. Sorrell, R. Handke, A. Harun, M. Phillips, Q. Nguyen, L. Delhaes, D. Ellis, W. Meyer and S. C. A. Chen, on behalf of the Australian Scedosporium Study Group |
Abstract: | Australia-wide population-based surveillance for scedosporiosis identified 180 cases, with 118 (65.6%) cases of colonization and 62 (34.4%) cases of infection. Predisposing factors for isolation of Scedosporium spp. included chronic lung disease in 37.8% and malignancy in 21.7% of cases. Predictors of invasive disease (n = 62) included haematological stem cell transplantation (n = 7), leukaemia (n = 16) and diabetes mellitus (n = 8). Of 183 phenotypically-speciated isolates, 75 (41%) were Scedosporium prolificans (risk factors: haematologic cancer (n = 17), neutropaenia (n = 14)) and 108 (59%) had Scedosporium apiospermum/Pseudallescheria boydii phenotype [risk factor: diabetes (n = 15)]. Scedosporium prolificans (p 0.01) and leukaemia (p 0.03) independently predicted death. Epidemiological and antifungal susceptibility profiles of Scedosporium aurantiacum (prevalence ≥15.8%) and S. apiospermum were similar. No patient with S. aurantiacum infection (n = 6) died. This is the first description of clinical features associated with S. aurantiacum. |
Keywords: | Epidemiology Scedosporium Scedosporium aurantiacum |
Description: | Article first published online: 22 JUN 2009 |
Rights: | Journal compilation © 2009 European Society of Clinical Microbiology and Infectious Diseases |
DOI: | 10.1111/j.1469-0691.2009.02802.x |
Published version: | http://dx.doi.org/10.1111/j.1469-0691.2009.02802.x |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
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