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https://hdl.handle.net/2440/58093
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Type: | Journal article |
Title: | ARABIDOPSIS TRITHORAX1 dynamically regulates FLOWERING LOCUS C activation via histone 3 lysine 4 trimethylation |
Author: | Pien, S. Fleury, D. Mylne, J. Crevillen, P. Inze, D. Avramova, Z. Dean, C. Grossniklaus, U. |
Citation: | The Plant Cell, 2008; 20(3):580-588 |
Publisher: | Amer Soc Plant Physiologists |
Issue Date: | 2008 |
ISSN: | 1040-4651 1532-298X |
Statement of Responsibility: | Stéphane Pien, Delphine Fleury, Joshua S. Mylne, Pedro Crevillen, Dirk Inzé, Zoya Avramova, Caroline Dean and Ueli Grossniklaus |
Abstract: | Trithorax function is essential for epigenetic maintenance of gene expression in animals, but little is known about trithorax homologs in plants. ARABIDOPSIS TRITHORAX1 (ATX1) was shown to be required for the expression of homeotic genes involved in flower organogenesis. Here, we report a novel function of ATX1, namely, the epigenetic regulation of the floral repressor FLOWERING LOCUS C (FLC). Downregulation of FLC accelerates the transition from vegetative to reproductive development in Arabidopsis thaliana. In the atx1 mutant, FLC levels are reduced and the FLC chromatin is depleted of trimethylated, but not dimethylated, histone 3 lysine 4, suggesting a specific trimethylation function of ATX1. In addition, we found that ATX1 directly binds the active FLC locus before flowering and that this interaction is released upon the transition to flowering. This dynamic process stands in contrast with the stable maintenance of homeotic gene expression mediated by trithorax group proteins in animals but resembles the dynamics of plant Polycomb group function. |
Keywords: | Chromatin Plants, Genetically Modified Histone-Lysine N-Methyltransferase Lysine MADS Domain Proteins Histones Arabidopsis Proteins Transcription Factors In Situ Hybridization Chromatin Immunoprecipitation Reverse Transcriptase Polymerase Chain Reaction Gene Expression Regulation, Plant Protein Binding Methylation Models, Biological |
Rights: | © 2008 American Society of Plant Biologists |
DOI: | 10.1105/tpc.108.058172 |
Published version: | http://dx.doi.org/10.1105/tpc.108.058172 |
Appears in Collections: | Agriculture, Food and Wine publications Aurora harvest 5 |
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