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Issue Date
Title
Author(s)
2002
Juxtamembrane mutant V560GKit is more sensitive to Imatinib (STI571) compared with wild-type c-kit whereas the kinase domain mutant D816VKit is resistant
Frost, M.
;
Ferrao, P.
;
Hughes, T.
;
Ashman, L.
2002
High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
Branford, S.
;
Rudzki, Z.
;
Walsh, S.
;
Grigg, A.
;
Arthur, C.
;
Taylor, K.
;
Herrmann, R.
;
Lynch, K.
;
Hughes, T.
2006
Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
Druker, B.
;
Guilhot, F.
;
O'Brien, S.
;
Gathmann, I.
;
Kantarjian, H.
;
Gattermann, N.
;
Deininger, M.
;
Silver, R.
;
Goldman, J.
;
Stone, R.
;
Cervantes, F.
;
Hochhaus, A.
;
Powell, B.
;
Gabrilove, J.
;
Rousselot, P.
;
Reiffers, J.
;
Cornelissen, J.
;
Hughes, T.
;
Agis, H.
;
Fischer, T.
;
et al.
2008
Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is active in patients with imatinib-resistant or -intolerant accelerated-phase chronic myelogenous leukemia
le Coutre, P.
;
Ottmann, O.
;
Giles, F.
;
Kim, D.
;
Cortes, J.
;
Gattermann, N.
;
Apperley, J.
;
Larson, R.
;
Abruzzese, E.
;
O'Brien, S.
;
Kuliczkowski, K.
;
Hochhaus, A.
;
Mahon, F.
;
Saglio, G.
;
Gobbi, M.
;
Kwong, Y.
;
Baccarani, M.
;
Hughes, T.
;
Martinelli, G.
;
Radich, J.
;
et al.
2006
Role of allogeneic stem cell transplantation for adult chronic myeloid leukemia in the imatinib era
Grigg, A.
;
Hughes, T.
2009
Imatinib mesylate causes growth plate closure in vivo
Vandyke, K.
;
Dewar, A.
;
Menicanin, D.
;
To, L.
;
Hughes, T.
;
Zannettino, A.
;
Fitter, S.
2005
Dynamics of chronic myeloid leukaemia
Michor, F.
;
Hughes, T.
;
Iwasa, Y.
;
Branford, S.
;
Shah, N.
;
Sawyers, C.
;
Nowak, M.
2003
Molecular monitoring of chronic myeloid leukemia
Hughes, T.
;
Branford, S.
2003
Imatinib inhibits the in vitro development of the monocyte/macrophage lineage from normal human bone marrow progenitors
Dewar, A.
;
Domaschenz, R.
;
Doherty, K.
;
Hughes, T.
;
Lyons, A.
2003
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
O'Brien, S.
;
Guilhot, F.
;
Larson, R.
;
Gathmann, I.
;
Baccarani, M.
;
Cervantes, F.
;
Cornelissen, J.
;
Fischer, T.
;
Hochhaus, A.
;
Hughes, T.
;
Lechner, K.
;
Nielsen, J.
;
Rousselot, P.
;
Reiffers, J.
;
Saglio, G.
;
Shepherd, J.
;
Simonsson, B.
;
Gratwohl, A.
;
Goldman, J.
;
Kantarjian, H.
;
et al.
Discover
Author
10
Branford, S.
9
Hochhaus, A.
7
Grigg, A.
7
To, L.
7
White, D.
7
Zannettino, A.
6
Dewar, A.
6
Lynch, K.
6
Saunders, V.
5
Rudzki, Z.
.
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Subject
30
Benzamides
30
Piperazines
30
Pyrimidines
23
Leukemia, Myelogenous, Chronic, B...
17
Antineoplastic Agents
16
Fusion Proteins, bcr-abl
11
Adult
11
Female
11
Male
10
Drug Resistance, Neoplasm
.
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2002