Adelaide Research & Scholarship
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https://hdl.handle.net/2440/60847
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| Type: | Journal article |
| Title: | Selective aggregation of a platinum-gadolinium complex within a tumor-cell nucleus |
| Author: | Crossley, E. Aitken, J. Vogt, S. Harris, H. Rendina, L. |
| Citation: | Angewandte Chemie International Edition, 2010; 49(7):1231-1233 |
| Publisher: | Wiley-V C H Verlag GMBH |
| Issue Date: | 2010 |
| ISSN: | 1433-7851 1521-3773 |
| Statement of Responsibility: | Ellen L. Crossley, Jade B. Aitken, Stefan Vogt, Hugh H. Harris and Louis M. Rendina |
| Abstract: | Hitching a ride: Treatment of A549 human lung carcinoma cells with a DNA metallointercalator complex results in the selective aggregation of the intact drug within the cell nuclei, as determined by synchrotron X-ray fluorescence (XRF) imaging (see images). This work is the first example of gadolinium delivery by a platinum complex to a tumor-cell nucleus. |
| Keywords: | Bioinorganic chemistry DNA gadolinium platinum tumors |
| Rights: | © 2010 Wiley-VCH Verlag GmbH |
| DOI: | 10.1002/anie.200902309 |
| Grant ID: | http://purl.org/au-research/grants/arc/DP0986055 http://purl.org/au-research/grants/arc/DP0984722 http://purl.org/au-research/grants/arc/DP0985807 http://purl.org/au-research/grants/arc/DP0986055 |
| Published version: | http://dx.doi.org/10.1002/anie.200902309 |
| Appears in Collections: | Aurora harvest Chemistry publications Environment Institute publications |
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