Adelaide Research & Scholarship
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https://hdl.handle.net/2440/61850
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| Type: | Journal article |
| Title: | Chemokine/Chemokine receptor interactions in extramedullary leukaemia of the skin in childhood AML: Differential roles for CCR2, CCR5, CXCR4 and CXCR7 |
| Author: | Faaij, C. Willemze, A. Revesz, T. Balzarolo, M. Tensen, C. Hoogeboom, M. Vermeer, M. van Wering, E. Zwaan, C. Kaspers, G. Story, C. van Halteren, A. Vossen, J. Egeler, R. van Tol, M. Annels, N. |
| Citation: | Pediatric Blood and Cancer, 2010; 55(2):344-348 |
| Publisher: | Wiley-Liss |
| Issue Date: | 2010 |
| ISSN: | 1545-5009 1545-5017 |
| Statement of Responsibility: | Claudia M.J.M. Faaij, Annemieke J. Willemze, Tom Révész, Melania Balzarolo, Cornelis P. Tensen, Manja Hoogeboom, Maarten H. Vermeer, Elisabeth van Wering, Christian M. Zwaan, Gertjan J.L. Kaspers, Colin Story, Astrid G.S. van Halteren, Jaak M. Vossen, R. Maarten Egeler, Maarten J.D. van Tol and Nicola E. Annels |
| Abstract: | Chemokine receptor/ligand interactions orchestrate the migration of cells to peripheral tissues such as the skin. We analysed chemokine receptor expression by acute myeloid leukaemic (AML) cells present in peripheral blood (n = 7), bone marrow (n = 6), or skin (n = 11) obtained from 15 paediatric AML patients with skin involvement and in 10 AML patients without skin involvement. High percentages of circulating CCR2(pos) AML cells were only detected in patients with extramedullary disease. Skin-residing AML cells displayed a different set of receptors in situ, namely: CCR5, CXCR4, CXCR7 and CX3CR1. These results suggest the involvement of different chemokine/chemokine receptor interactions in homing and retention of AML blasts in the skin. |
| Keywords: | Skin Humans Skin Neoplasms Leukemic Infiltration Receptors, Chemokine Receptors, CCR5 Receptors, CXCR4 Chemokines Case-Control Studies Adolescent Child Child, Preschool Infant Infant, Newborn Female Male Leukemia, Myeloid, Acute Receptors, CXCR Receptors, CCR2 CX3C Chemokine Receptor 1 |
| Rights: | Copyright © 2010 Wiley-Liss, Inc. |
| DOI: | 10.1002/pbc.22500 |
| Published version: | http://dx.doi.org/10.1002/pbc.22500 |
| Appears in Collections: | Aurora harvest 5 Paediatrics publications |
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