Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/62094
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Alsamak, F. | - |
dc.contributor.author | Abdulamir, A. | - |
dc.contributor.author | Mahdi, L. | - |
dc.contributor.author | Alnaib, K. | - |
dc.contributor.author | Bakar, F. | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Asian Biomedicine, 2010; 4(4):609-618 | - |
dc.identifier.issn | 1905-7415 | - |
dc.identifier.issn | 1875-855X | - |
dc.identifier.uri | http://hdl.handle.net/2440/62094 | - |
dc.description.abstract | Background: Helicobacter pylori (H. pylori) may be associated with colorectal cancer. However, the underlying mechanisms are still unclear. Objectives: Explore the serostatus of H. pylori cytotoxicity-associated gene A product (CagA) in patients with colorectal carcinoma, and assess the association of H. pylori with colorectal cancer via c-Myc and MUC-2 proteins at tumor tissues. Methods: H. pylori CagA IgG antibodies were screened using enzyme-linked immunosorbent assay (ELISA) in 30 patients with colorectal carcinoma and 30 cancer-free control subjects. Paraffin-embedded blocks were examined for the expression of c-Myc and MUC-2 protein by immunohistochemistry. Results: H. pylori CagA seropositivity increased significantly among colorectal cancer patients (p <0.05). The expression of c-Myc and MUC-2 in colorectal carcinoma patients was over-expressed (80%), and downexpressed (63%) in resection margins (p <0.05). c-Myc over-expression and MUC-2 down-expression were associated with CagA-positive rather than CagA-negative H. pylori patients. In 16 CagA seropositive vs. 14 CagA seronegative patients, the expression rate was 97.3% vs. 64.2% and 33.3% vs. 78.5% for cMyc and MUC-2, respectively. CagA IgG level was significantly higher in positive than in negative c-Myc patients (p= 0.036), and in negative than in positive MUC-2 patients (p= 0.044). c-Myc and MUC-2 were positively and inversely correlated with CagA IgG level (p <0.05). Conclusions: CagA-seropositive H. pylori is most probably associated with colorectal cancer development. Part of the underlying mechanism for such association might be via alterations in expression of MUC-2, which depletes the mucous protective layer in the colo-rectum, and c-Myc, which stimulates the growth of cancerous cells. | - |
dc.description.statementofresponsibility | Fadi Fouad Alsamak, Ahmed Sahib Abdulamir, Laila Khalid Mahdi, Khalid Alnaib and Fatimah Abu Bakar | - |
dc.description.uri | http://www.asianbiomed.org/AutoJournal.php | - |
dc.language.iso | en | - |
dc.publisher | Chulalongkorn University | - |
dc.rights | Copyright status unknown | - |
dc.source.uri | http://www.asianbiomed.org/htdocs/previous/A20104609.pdf | - |
dc.subject | Helicobacter pylori | - |
dc.subject | colorectal cancer | - |
dc.subject | Cag-A | - |
dc.subject | MUC-2 | - |
dc.title | Association of Helicobacter pylori with colorectal cancer development | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.2478/abm-2010-0077 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Mahdi, L. [0000-0002-5878-8385] | - |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.