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https://hdl.handle.net/2440/63142
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Type: | Journal article |
Title: | Spherical N-carboxyethylchitosan/hydroxyapatite nanoparticles prepared by ionic diffusion process in a controlled manner |
Author: | Zhu, A. Lu, Y. Zhou, Y. Dai, S. |
Citation: | Journal of Materials Science: Materials in Medicine, 2010; 21(12):3095-3101 |
Publisher: | Kluwer Academic Publ |
Issue Date: | 2010 |
ISSN: | 0957-4530 1573-4838 |
Statement of Responsibility: | Aiping Zhu, Yan Lu, Yao Zhou, Sheng Dai |
Abstract: | The nanocomposites containing hydroxyapatite (HA) and biomacromolecules have attracted considerable research interest in implants, tissue scaffolds and drug controlled delivery. In this study, the N-carboxyethylchitosan/hydroxyapatite (NCECS/HA) nanoparticles were prepared by the ionic diffusion process in a controlled manner. The crystallization, particle size, size distribution and aggregation morphology of the NCECS/HA nanocomposites were dependent on the mole ratio of the glucosamine unit in NCECS to the Ca(2+). Fourier transform-infrared spectroscopic (FTIR) result indicated that there are chemical bonds formed between NCECS and HA. X-ray diffraction (XRD) analysis showed that the crystallization of HA in NCECS matrix was significantly retarded. Transmission electron microscopy (TEM) results revealed that NCECS/HA nanocomposites have the spherical morphology with the diameter ranging from 10 to 40 nm. The NCECS mineralization is driven by the self-assembly of NCECS and HA. These NCECS/HA nanocomposites have potential applications as the carrier for the controlled delivery of growth factors and drugs. |
Keywords: | Durapatite Water Chitosan Microscopy, Electron, Transmission Crystallization X-Ray Diffraction Spectroscopy, Fourier Transform Infrared Tissue Engineering Microspheres Diffusion Phase Transition Models, Biological Nanoparticles Tissue Scaffolds |
Rights: | © Springer Science+Business Media, LLC 2010 |
DOI: | 10.1007/s10856-010-4157-7 |
Grant ID: | 08KJA430003 |
Published version: | http://dx.doi.org/10.1007/s10856-010-4157-7 |
Appears in Collections: | Aurora harvest 5 Chemical Engineering publications |
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