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https://hdl.handle.net/2440/6316
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DC Field | Value | Language |
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dc.contributor.author | Freed, E. | - |
dc.contributor.author | Goldney, R. | - |
dc.contributor.author | Lambert, T. | - |
dc.contributor.author | Tiller, J. | - |
dc.contributor.author | Johnston, R. | - |
dc.date.issued | 1999 | - |
dc.identifier.citation | Australian and New Zealand Journal of Psychiatry, 1999; 33(3):416-421 | - |
dc.identifier.issn | 0004-8674 | - |
dc.identifier.issn | 1440-1614 | - |
dc.identifier.uri | http://hdl.handle.net/2440/6316 | - |
dc.description.abstract | <h4>Objective</h4>This study compared the tolerability and efficacy of paroxetine and amitriptyline in the treatment of depression in general practice.<h4>Methods</h4>In this double-blind, multicentre study conducted in the general practice, patients with depression (Montgomery Asberg Depression Rating Scale [MADRS] score > or = 20) who were regarded as requiring antidepressant therapy were randomly assigned to receive paroxetine (20 mg, n = 184) or amitriptyline (50-100 mg, n = 191) once daily for 9 weeks.<h4>Results</h4>More patients completed treatment with paroxetine than with amitriptyline (71.1% vs 56.1%, p = 0.009). Depression rating scores (MADRS and Clinical Global Impression [CGI]) were improved with both agents, but at week 9, paroxetine achieved more favourable scores compared with amitriptyline on MADRS (p=0.019), CGI severity of depression (p=0.044), and CGI efficacy index (p = 0.038).<h4>Conclusions</h4>Depressed patients treated in general practice respond more quickly and are more likely to complete the treatment regimen with paroxetine than with amitriptyline. | - |
dc.description.statementofresponsibility | Edgar Freed, Robert Goldney, Timothy Lambert, John Tiller, Robyn Johnston | - |
dc.language.iso | en | - |
dc.publisher | SAGE Publications | - |
dc.source.uri | http://dx.doi.org/10.1046/j.1440-1614.1999.00565.x | - |
dc.subject | Humans | - |
dc.subject | Paroxetine | - |
dc.subject | Amitriptyline | - |
dc.subject | Antidepressive Agents, Second-Generation | - |
dc.subject | Antidepressive Agents, Tricyclic | - |
dc.subject | Treatment Outcome | - |
dc.subject | Drug Administration Schedule | - |
dc.subject | Chi-Square Distribution | - |
dc.subject | Double-Blind Method | - |
dc.subject | Depressive Disorder | - |
dc.subject | Time Factors | - |
dc.subject | Adult | - |
dc.subject | Aged | - |
dc.subject | Aged, 80 and over | - |
dc.subject | Middle Aged | - |
dc.subject | Primary Health Care | - |
dc.subject | Australia | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Selective Serotonin Reuptake Inhibitors | - |
dc.title | A double-blind, multicentre study to assess the tolerability and efficacy of paroxetine compared with amitriptyline in the treatment of depressed patients in Australian general practice | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1046/j.1440-1614.1999.00565.x | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest Psychiatry publications |
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