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https://hdl.handle.net/2440/64414
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DC Field | Value | Language |
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dc.contributor.author | Hilder, T. | - |
dc.contributor.author | Hill, J. | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Journal of Computational and Theoretical Nanoscience, 2008; 5(11):2153-2159 | - |
dc.identifier.issn | 1546-1955 | - |
dc.identifier.issn | 1546-1963 | - |
dc.identifier.uri | http://hdl.handle.net/2440/64414 | - |
dc.description.abstract | Functionalized nanoparticles and nanotubes may be able to target specific cells, become ingested and then release their contents in response to a chemical trigger. An alternative delivery mechanism, which may offer advantages in drug delivery is the use of a nanosyringe which pierces the cell membrane and injects molecules such as DNA or anticancer drugs directly into the cell. Here, we propose the use of double-walled carbon nanotubes as nanosyringes. By way of illustration we investigate the suction and expulsion mechanisms, using elementary mechanics and applied mathematical modeling techniques, for both a C₆₀ fullerene and the anticancer drug cisplatin, but similar calculations can be undertaken for any molecule. Some specific guidelines are formulated to assist medical scientists to facilitate nanosyringe development. | - |
dc.description.statementofresponsibility | Tamsyn A. Hilder, James M. Hill | - |
dc.language.iso | en | - |
dc.publisher | American Scientific Publishers | - |
dc.rights | Copyright status unknown | - |
dc.source.uri | http://dx.doi.org/10.1166/jctn.2008.1112 | - |
dc.subject | nanosyringe | - |
dc.subject | mechanics | - |
dc.subject | Cisplatin | - |
dc.subject | fullerene | - |
dc.subject | loading/unloading | - |
dc.title | Double-Walled Carbon Nanotubes as Nanosyringes | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1166/jctn.2008.1112 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest Mathematical Sciences publications |
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