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https://hdl.handle.net/2440/65121
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Type: | Journal article |
Title: | An immune paradox: how can the same chemokine axis regulate both immune tolerance and activation? CCR6/CCL20: a chemokine axis balancing immunological tolerance and inflammation in autoimmune disease |
Author: | Comerford, I. Bunting, M. Fenix, K. Haylock-Jacobs, S. Litchfield, W. Harata-Lee, Y. Turvey, M. Brazzatti, J. Gregor, C. Nguyen, P. Kara, E. McColl, S. |
Citation: | BioEssays, 2010; 32(12):1067-1076 |
Publisher: | John Wiley & Sons, Inc. |
Issue Date: | 2010 |
ISSN: | 0265-9247 1521-1878 |
Statement of Responsibility: | Iain Comerford, Mark Bunting, Kevin Fenix, Sarah Haylock-Jacobs, Wendel Litchfield, Yuka Harata-Lee, Michelle Turvey, Julie Brazzatti, Carly Gregor, Phillip Nguyen, Ervin Kara and Shaun R. McColl |
Abstract: | Chemokines (chemotactic cytokines) drive and direct leukocyte traffic. New evidence suggests that the unusual CCR6/CCL20 chemokine receptor/ligand axis provides key homing signals for recently identified cells of the adaptive immune system, recruiting both pro-inflammatory and suppressive T cell subsets. Thus CCR6 and CCL20 have been recently implicated in various human pathologies, particularly in autoimmune disease. These studies have revealed that targeting CCR6/CCL20 can enhance or inhibit autoimmune disease depending on the cellular basis of pathogenesis and the cell subtype most affected through different CCR6/CCL20 manipulations. Here, we discuss the significance of this chemokine receptor/ligand axis in immune and inflammatory functions, consider the potential for targeting CCR6/CCL20 in human autoimmunity and propose that the shared evolutionary origins of pro-inflammatory and regulatory T cells may contribute to the reason why both immune activation and regulation might be controlled through the same chemokine pathway. |
Keywords: | autoimmunity CCL20 CCR6 chemokine Th17 |
Rights: | © 2010 WILEY Periodicals, Inc. |
DOI: | 10.1002/bies.201000063 |
Published version: | http://dx.doi.org/10.1002/bies.201000063 |
Appears in Collections: | Aurora harvest IPAS publications Molecular and Biomedical Science publications |
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