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https://hdl.handle.net/2440/65812
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Type: | Journal article |
Title: | Monoamine oxidase A variant influences antidepressant treatment response in female patients with Major Depression |
Author: | Domschke, K. Hohoff, C. Mortensen, L. Roehrs, T. Deckert, J. Arolt, V. Baune, B. |
Citation: | Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2008; 32(1):224-228 |
Publisher: | Pergamon-Elsevier Science Ltd |
Issue Date: | 2008 |
ISSN: | 0278-5846 1878-4216 |
Statement of Responsibility: | Katharina Domschke, Christa Hohoff, Lena S. Mortensen, Tilmann Roehrs, Jürgen Deckert, Volker Arolt, Bernhard T. Baune |
Abstract: | The monoamine oxidase A (MAO-A) has been suggested to be involved in the pathogenesis as well as the pharmacological treatment of Major Depression. In the present study, 340 patients with a Major Depressive Episode (f=194, m=146; DSM-IV) of Caucasian descent were genotyped for the functional MAO-A VNTR. The clinical response to antidepressive pharmacological treatment was assessed by weekly intra-individual changes of HAM-D-21 scores over six weeks. The longer MAO-A alleles (3a, 4, 5) conferred a significant risk of slower and less efficient overall response over the course of 6 weeks of antidepressant treatment in patients with Major Depression, with the effect being restricted to female patients (p=0.028; corrected for multiple testing). The present results suggest that high-activity MAO-A genotypes possibly by consecutively decreased serotonin and/or norepinephrine availability negatively influence antidepressant treatment response during the first six weeks of pharmacological treatment in female patients with Major Depression. |
Keywords: | Antidepressant treatment Major Depression Monoamine oxidase A Pharmacogenetics VNTR |
Rights: | © 2007 Elsevier Inc. All rights reserved. |
DOI: | 10.1016/j.pnpbp.2007.08.011 |
Published version: | http://dx.doi.org/10.1016/j.pnpbp.2007.08.011 |
Appears in Collections: | Aurora harvest 5 Psychiatry publications |
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