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https://hdl.handle.net/2440/68274
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Type: | Journal article |
Title: | Probiotic factors partially improve parameters of 5-fluorouracil-induced intestinal mucositis in rats |
Author: | Prisciandaro, L. Geier, M. Butler, R. Cummins, A. Howarth, G. |
Citation: | Cancer Biology and Therapy, 2011; 11(7):671-677 |
Publisher: | Landes Bioscience |
Issue Date: | 2011 |
ISSN: | 1538-4047 1555-8576 |
Statement of Responsibility: | Luca D. Prisciandaro, Mark S. Geier, Ross N. Butler, Adrian G. Cummins and Gordon S. Howarth |
Abstract: | Certain live bacteria have demonstrated preliminary indications of efficacy for the treatment of chemotherapy-induced intestinal mucositis. However, probiotic derived supernatants (SN) have yet to be investigated in the mucositis setting. We evaluated SN from Escherichia coli Nissle 1917 (EcN) and Lactobacillus fermentum BR11 (BR11) for their capacity to decrease 5-Fluorouracil (5-FU)-induced damage in vivo. Female Dark Agouti rats were gavaged with 1mL of either SN or vehicle daily (days 0-8) and intraperitoneally injected with 5-FU (150mg/kg) on day 5 to induce mucositis. On day 9, animals were culled and intestinal tissues collected. Significantly lower histological damage scores were apparent in the jejunum of 5-FU treated rats receiving SN compared to 5-FU controls. Myeloperoxidase levels in the jejunum of 5-FU treated rats were increased in vehicle and BR11 SN treatments compared to untreated controls, whereas no significant increase was observed after EcN SN treatment. 5-FU treatment significantly reduced villus height and crypt depth in the jejunum compared to normal controls; however no significant reduction in these parameters was observed in 5-FU treated rats receiving either SN. We conclude that bacterial SN, especially EcN, partially protect the intestine from 5-FU mucositis. Further studies are required to define specific mechanisms by which SN exert their beneficial effects. |
Keywords: | Intestinal Mucosa Intestine, Small Animals Rats Fluorouracil Sucrase Peroxidase Mucins Severity of Illness Index Enzyme Activation Probiotics Female Mucositis |
Rights: | Copyright status unknown |
DOI: | 10.4161/cbt.11.7.14896 |
Published version: | http://dx.doi.org/10.4161/cbt.11.7.14896 |
Appears in Collections: | Animal and Veterinary Sciences publications Aurora harvest |
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