Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/68314
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dc.contributor.author | Liu, L. | - |
dc.contributor.author | Ghosh, N. | - |
dc.contributor.author | Slivka, P. | - |
dc.contributor.author | Fiorini, Z. | - |
dc.contributor.author | Hutchinson, M. | - |
dc.contributor.author | Watkins, L. | - |
dc.contributor.author | Yin, H. | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | ChemBioChem: a European journal of chemical biology, 2011; 12(12):1827-1831 | - |
dc.identifier.issn | 1439-4227 | - |
dc.identifier.issn | 1439-7633 | - |
dc.identifier.uri | http://hdl.handle.net/2440/68314 | - |
dc.description.abstract | A truncated peptide was shown to retain the structure of the TLR4-binding hot-spot region of MD2, disrupting with the TLR4/MD2 interactions. The peptide not only demonstrated strong binding affinity in the fluorescence polarization assay, but also showed high specificity in macrophage cells. Furthermore, MD2-I was able to suppress neuropathic pain in animal models. | - |
dc.description.statementofresponsibility | Liping Liu, Nilanjan Ghosh, Peter F. Slivka, Zeno Fiorini, Mark R. Hutchinson, Linda R. Watkins and Hang Yin | - |
dc.language.iso | en | - |
dc.publisher | Wiley-VCH Verlag GMBH | - |
dc.rights | Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim | - |
dc.source.uri | http://dx.doi.org/10.1002/cbic.201100211 | - |
dc.subject | Neuroglia | - |
dc.subject | Cell Line | - |
dc.subject | Macrophages | - |
dc.subject | Animals | - |
dc.subject | Humans | - |
dc.subject | Mice | - |
dc.subject | Rats | - |
dc.subject | Neuralgia | - |
dc.subject | Inflammation | - |
dc.subject | Nitrobenzenes | - |
dc.subject | Azoles | - |
dc.subject | Lipopolysaccharides | - |
dc.subject | Peptide Fragments | - |
dc.subject | Spectrometry, Fluorescence | - |
dc.subject | T-Cell Antigen Receptor Specificity | - |
dc.subject | Molecular Mimicry | - |
dc.subject | Amino Acid Sequence | - |
dc.subject | Protein Binding | - |
dc.subject | Molecular Sequence Data | - |
dc.subject | Toll-Like Receptor 4 | - |
dc.subject | Lymphocyte Antigen 96 | - |
dc.subject | Molecular Dynamics Simulation | - |
dc.subject | Pain Management | - |
dc.title | An MD2 hot-spot-mimicking peptide that suppresses TLR4-mediated inflammatory response in vitro and in vivo | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1002/cbic.201100211 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/DP110100297 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Hutchinson, M. [0000-0003-2154-5950] | - |
Appears in Collections: | Aurora harvest Earth and Environmental Sciences publications Environment Institute publications |
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