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https://hdl.handle.net/2440/69003
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dc.contributor.author | Iwajomo, O. | - |
dc.contributor.author | Finn, A. | - |
dc.contributor.author | Moons, P. | - |
dc.contributor.author | Nkhata, R. | - |
dc.contributor.author | Sepako, E. | - |
dc.contributor.author | Ogunniyi, A. | - |
dc.contributor.author | Williams, N. | - |
dc.contributor.author | Heyderman, R. | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Journal of Infectious Diseases, 2011; 204(4):534-543 | - |
dc.identifier.issn | 1537-6613 | - |
dc.identifier.issn | 1537-6613 | - |
dc.identifier.uri | http://hdl.handle.net/2440/69003 | - |
dc.description.abstract | Invasive pneumococcal disease is a leading cause of human immunodeficiency virus (HIV)–associated mortality in sub-Saharan African children. Defective T-cell–mediated immunity partially explains this high disease burden, but there is an increased risk of invasive pneumococcal disease even in the context of a relatively preserved percentage of CD4 cells. We hypothesized that impaired B-cell immunity to this pathogen further amplifies the immune defect. We report a shift in the B-cell compartment toward an apoptosis-prone phenotype evident early in HIV disease progression. We show that, although healthy HIV-uninfected and minimally symptomatic HIV-infected children have similar numbers of isotype-switched memory B cells, numbers of pneumococcal protein antigen–specific memory B cells were lower in HIV-infected than in HIV-uninfected children. Our data implicate defective naturally acquired B-cell pneumococcal immunity in invasive pneumococcal disease causation in HIV-infected children and highlight the need to study the functionality and duration of immune memory to novel pneumococcal protein vaccine candidates in order to optimize their effectiveness in this population. | - |
dc.description.statementofresponsibility | Oluwadamilola H. Iwajomo, Adam Finn, Peter Moons, Rose Nkhata, Enoch Sepako, Abiodun D. Ogunniyi, Neil A. Williams, and Robert S. Heyderman | - |
dc.language.iso | en | - |
dc.publisher | Oxford University Press | - |
dc.rights | © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1093/infdis/jir316 | - |
dc.subject | B-Lymphocytes | - |
dc.subject | CD4-Positive T-Lymphocytes | - |
dc.subject | Humans | - |
dc.subject | Streptococcus pneumoniae | - |
dc.subject | Pneumococcal Infections | - |
dc.subject | HIV Infections | - |
dc.subject | Immunoglobulin G | - |
dc.subject | Immunoglobulin M | - |
dc.subject | CD40 Ligand | - |
dc.subject | CD4 Lymphocyte Count | - |
dc.subject | Carrier State | - |
dc.subject | Immunoglobulin Class Switching | - |
dc.subject | Immunologic Memory | - |
dc.subject | Child | - |
dc.subject | Child, Preschool | - |
dc.subject | Infant | - |
dc.subject | Malawi | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Enzyme-Linked Immunospot Assay | - |
dc.title | Deteriorating pneumococcal-specific B-cell memory in minimally symptomatic African children with HIV infection | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1093/infdis/jir316 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Ogunniyi, A. [0000-0001-9308-5629] | - |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
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