Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/69537
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Are underlying assumptions of current animal models of human stroke correct: From STAIRs to high hurdles? |
Author: | Turner, R. Jickling, G. Sharp, F. |
Citation: | Translational Stroke Research, 2011; 2(2):138-143 |
Publisher: | Springer New York LLC |
Issue Date: | 2011 |
ISSN: | 1868-4483 1868-601X |
Statement of Responsibility: | Renée J. Turner, Glen C. Jickling, Frank R. Sharp |
Abstract: | Animal models of acute ischemic stroke have been criticized for failing to translate to human stroke. Nevertheless, animal models are necessary to improve our understanding of stroke pathophysiology and to guide the development of new stroke therapies. The rabbit embolic clot model is one animal model that has led to an effective therapy in human acute ischemic stroke, namely tissue plasminogen activator (tPA). We propose that potential compounds that demonstrate efficacy in non-rabbit animal models of acute ischemic stroke should also be tested in the rabbit embolic blood clot model and, where appropriate, compared to tPA prior to investigation in humans. Furthermore, the use of anesthesia needs to be considered as a major confounder in animal models of acute ischemic stroke, and death should be included as an outcome measure in animal stroke studies. These steps, along with the current STAIRs recommendations, may improve the successful translation of experimental therapies to clinical stroke treatments. |
Keywords: | Cerebral ischemia Stroke Animal models Neuroprotection issue plasminogen activator Rabbit |
Rights: | © The Author(s) 2011. |
DOI: | 10.1007/s12975-011-0067-3 |
Published version: | http://dx.doi.org/10.1007/s12975-011-0067-3 |
Appears in Collections: | Aurora harvest Pathology publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.