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https://hdl.handle.net/2440/71597
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dc.contributor.author | Cannon, P. | - |
dc.contributor.author | Cruz, A. | - |
dc.contributor.author | Carolina, P. | - |
dc.contributor.author | Mastropietro, D. | - |
dc.contributor.author | Chahud, F. | - |
dc.contributor.author | Bilyk, J. | - |
dc.contributor.author | Selva-Nayagam, D. | - |
dc.contributor.author | Prabhakaran, V. | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Orbit: the international journal on orbital disorders, oculoplastic and lacrimal surgery, 2011; 30(2):64-69 | - |
dc.identifier.issn | 0167-6830 | - |
dc.identifier.issn | 1744-5108 | - |
dc.identifier.uri | http://hdl.handle.net/2440/71597 | - |
dc.description.abstract | INTRODUCTION: To describe our attempt in establishing a definitive diagnosis in patients with hypertrophic pachymeningitis in combination with orbital inflammatory disease and report on the outcome. MATERIALS AND METHODS: This was a retrospective case series of all patients presenting with hypertrophic pachymeningitis in association with orbital inflammation in 4 centres. Ophthalmic and neurological examination data, laboratory data, histology data, treatment plans and clinical outcome data were recorded. Patients underwent orbital/brain computed tomography and magnetic resonance imaging. RESULTS: Six patients were identified; the median age was 46.5 years. Headache was the commonest presenting symptom, followed by diplopia and reduced visual acuity. Three patients underwent orbital biopsy, 1 patient underwent dura mater biopsy, 1 patient underwent both and 1 patient underwent nasal biopsy. Four patients were diagnosed with Wegener granulomatosis and 2 patients with tuberculosis. Corticosteroid therapy was initiated in 4 patients, with steroid-sparing drugs added later. Two patients received anti-tuberculosis treatment and 1 patient was commenced on pulsed cyclophosphamide. On follow-up, 1 patient required an exenteration for a painful blind eye and 1 patient’s visual acuity remained at no perception to light. One patient had complete resolution of symptoms on treatment, 1 patient had persistent reduced visual acuity and 1 patient was lost to follow-up. CONCLUSION: We postulate that the combination of orbital inflammation and pachymeningitis is strongly suggestive of Wegener granulomatosis, although it may take a number of years to confirm. Tuberculosis should also be considered. | - |
dc.description.statementofresponsibility | Paul S. Cannon, Antonio A.V. Cruz, Carolina T. Pinto, Dante A. Mastropietro, Fernando Chahud, Jurij R. Bilyk, Dinesh Selva and Venkatesh C. Prabhakaran | - |
dc.language.iso | en | - |
dc.publisher | Taylor & Francis The Netherlands | - |
dc.rights | Copyright © 2011 Informa Healthcare USA, Inc. | - |
dc.source.uri | http://dx.doi.org/10.3109/01676830.2010.539766 | - |
dc.subject | Orbital inflammation | - |
dc.subject | hypertrophic pachymeningitis | - |
dc.subject | aetiology | - |
dc.subject | Wegener's granulomatosis | - |
dc.subject | Tuberculosis | - |
dc.title | A multi-centre case series investigating the aetiology of hypertrophic pachymeningitis with orbital inflammation | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.3109/01676830.2010.539766 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Selva-Nayagam, D. [0000-0002-2169-5417] | - |
Appears in Collections: | Aurora harvest Opthalmology & Visual Sciences publications |
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