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https://hdl.handle.net/2440/72040
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Type: | Journal article |
Title: | Life-course socioeconomic position and Type 2 Diabetes Mellitus: the Framingham offspring study |
Author: | Smith, B. Lynch, J. Fox, C. Harper, S. Abrahamowicz, M. Almeida, N. Loucks, E. |
Citation: | American Journal of Epidemiology, 2011; 173(4):438-447 |
Publisher: | Oxford Univ Press Inc |
Issue Date: | 2011 |
ISSN: | 0002-9262 1476-6256 |
Statement of Responsibility: | Brendan T. Smith, John W. Lynch, Caroline S. Fox, Sam Harper, Michal Abrahamowicz, Nisha D. Almeida, and Eric B. Loucks |
Abstract: | Evidence is lacking on whether the duration and timing of low socioeconomic position (SEP) across a person’s life course may be associated with incidence of type 2 diabetes mellitus (T2D). The authors’ objectives were to investigate associations between cumulative SEP and the incidence of T2D in the Framingham Offspring Study (n ¼ 1,893; 52% women; mean baseline age ¼ 34 years). Pooled logistic regression analyses demonstrated that age-adjusted cumulative SEP was associated with T2D in women (for low vs. high cumulative SEP, odds ratio (OR) ¼ 1.92, 95% confidence interval (CI): 1.08, 3.42). Age-adjusted analyses for young-adulthood SEP (7.85 for _12 vs. >16 years of education, OR ¼ 2.84, 95% CI: 1.03), active professional life SEP (for laborer versus professional or executive or supervisory or technical occupations, OR ¼ 2.40, 95% CI: 1.05, 5.47), and social-mobility frameworks (for declining life-course SEP, OR ¼ 2.99, 95% CI: 1.39, 6.44; for stable low vs. stable high life-course SEP, OR ¼ 1.85, 95% CI: 1.02, 3.35) all demonstrated associations between low SEP and T2D incidence in women. No association was observed between childhood SEP and T2D in women for father’s education (some high school or less vs. any postsecondary education, OR ¼ 1.26, 95% CI: 0.72, 2.22). In men, there was little evidence of associations between life-course SEP and T2D incidence. These findings suggest that cumulative SEP is inversely associated with incidence of T2D in women, and that this association may be primarily due to the women’s educational levels and occupations. |
Keywords: | Adult Diabetes mMllitus educational status incidence occupations parents risk factors socioeconomic factors |
Rights: | © The Author 2011. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School ofPublic Health. All rights reserved |
DOI: | 10.1093/aje/kwq379 |
Published version: | http://dx.doi.org/10.1093/aje/kwq379 |
Appears in Collections: | Aurora harvest 5 Medicine publications |
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