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https://hdl.handle.net/2440/73039
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dc.contributor.author | Zvarec, O. | - |
dc.contributor.author | Polyak, S. | - |
dc.contributor.author | Tieu, W. | - |
dc.contributor.author | Kuan, K. | - |
dc.contributor.author | Dai, H. | - |
dc.contributor.author | Pedersen, D. | - |
dc.contributor.author | Morona, R. | - |
dc.contributor.author | Zhang, L. | - |
dc.contributor.author | Booker, G. | - |
dc.contributor.author | Abell, A. | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Bioorganic and Medicinal Chemistry Letters, 2012; 22(8):2720-2722 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.issn | 1464-3405 | - |
dc.identifier.uri | http://hdl.handle.net/2440/73039 | - |
dc.description.abstract | Herein we outline the antibacterial activity of amino acid containing thiazolidinediones and rhodanines against Gram-positive bacteria Staphylococcus aureus ATCC 31890, Staphylococcus epidermidis and Bacillus subtilis ATCC 6633. The rhodanine derivatives were generally more active than the analogous thiazolidinediones. Compounds of series 5 showed some selectivity for Bacillus subtilis ATCC 6633, the extent of which is enhanced by the inclusion of a non-polar amino acid at the 5-position of the core thiazolidinediones and rhodanines scaffolds. SAR data of series 8 demonstrated improved activity against the clinically more significant Staphylococci with selectivity over Bacillus subtilis ATCC 6633 induced by introduction of a bulky aryl substituent at the 5-position of the core scaffolds. | - |
dc.description.statementofresponsibility | Ondrej Zvarec, Steven W. Polyak, William Tieu, Kevin Kuan, Huanqin Dai, Daniel Sejer Pedersen, Renato Morona, Lixin Zhang, Grant W. Booker, Andrew D. Abell | - |
dc.language.iso | en | - |
dc.publisher | Pergamon-Elsevier Science Ltd | - |
dc.rights | Copyright © 2012 Elsevier Ltd. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.bmcl.2012.02.100 | - |
dc.subject | Privileged scaffold | - |
dc.subject | Thiazolidinedione | - |
dc.subject | Rhodanines | - |
dc.subject | Antibacterial | - |
dc.subject | Staphylococcus aureus | - |
dc.title | 5-Benzylidenerhodanine and 5-benzylidene-2-4-thiazolidinedione based antibacterials | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.bmcl.2012.02.100 | - |
dc.relation.grant | ARC | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Polyak, S. [0000-0002-8458-5194] | - |
dc.identifier.orcid | Tieu, W. [0000-0002-7161-4152] | - |
dc.identifier.orcid | Morona, R. [0000-0001-7009-7440] | - |
dc.identifier.orcid | Booker, G. [0000-0001-7207-4699] | - |
dc.identifier.orcid | Abell, A. [0000-0002-0604-2629] | - |
Appears in Collections: | Aurora harvest IPAS publications Molecular and Biomedical Science publications |
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