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https://hdl.handle.net/2440/7519
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DC Field | Value | Language |
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dc.contributor.author | Blank, C. | - |
dc.contributor.author | Neumann, M. | - |
dc.contributor.author | Makrides, M. | - |
dc.contributor.author | Gibson, R. | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Journal of Lipid Research, 2002; 43(9):1537-1543 | - |
dc.identifier.issn | 0022-2275 | - |
dc.identifier.issn | 1539-7262 | - |
dc.identifier.uri | http://hdl.handle.net/2440/7519 | - |
dc.description.abstract | We examined the effect of altering the linoleic acid (LA, 18:2n-6) to α-linolenic acid (ALA, 18:3n-3) ratio in the dietary fats of 3 day old piglets fed formula for 3 weeks. The LA-ALA ratios of the experimental formulas were 0.5:1, 1:1, 2:1, 4:1, and 10:1. The level of LA was held constant at 13% of total fats while the level of ALA varied from 1.3% (10:1 group) to 26.8% (0.5:1 group). Incorporation of the n-3 long chain PUFA EPA and 22:5n-3 into erythrocytes, plasma, liver, and brain tissues was linearly related to dietary ALA. Conversely, incorporation of DHA into all tissues was related to dietary ALA in a curvilinear manner, with the maximum incorporation of DHA appearing to be between the LA-ALA ratios of 4:1 and 2:1. Feeding LA-ALA ratios of 10:1 and 0.5:1 resulted in lower and similar proportions of DHA in tissues despite the very different levels of dietary ALA (1.3 vs. 26.8% of total fats, respectively). These results are relevant to term infant studies in that they confirm our earlier findings of the positive effect on DHA status by lowering the LA-ALA ratio from 10:1 to 3:1 or 4:1, and they predict that ratios of LA-ALA below 4:1 would have little further beneficial effect on DHA status. | - |
dc.description.statementofresponsibility | Cordula Blank, Mark A. Neumann, Maria Makrides, and Robert A. Gibson | - |
dc.language.iso | en | - |
dc.publisher | Lipid Research Inc | - |
dc.source.uri | http://dx.doi.org/10.1194/jlr.m200152-jlr200 | - |
dc.subject | Brain | - |
dc.subject | plasma | - |
dc.subject | fatty acid metabolism | - |
dc.subject | formula | - |
dc.title | Optimizing DHA levels in piglets by lowering the linoleic acid to a-linolenic acid ratio | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1194/jlr.M200152-JLR200 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Makrides, M. [0000-0003-3832-541X] | - |
dc.identifier.orcid | Gibson, R. [0000-0002-8750-525X] | - |
Appears in Collections: | Aurora harvest 5 Paediatrics publications |
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