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https://hdl.handle.net/2440/75938
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Type: | Journal article |
Title: | Prospects of nanoparticle-DNA binding and its implications in medical biotechnology |
Author: | An, H. Jin, B. |
Citation: | Biotechnology Advances, 2012; 30(6):1721-1732 |
Publisher: | Pergamon-Elsevier Science Ltd |
Issue Date: | 2012 |
ISSN: | 0734-9750 1873-1899 |
Statement of Responsibility: | Hongjie An, Bo Jin |
Abstract: | Bio-nanotechnology is a new interdisciplinary R&D area that integrates engineering and physical science with biology through the development of multifunctional devices and systems, focusing biology inspired processes or their applications, in particular in medical biotechnology. DNA based nanotechnology, in many ways, has been one of the most intensively studied fields in recent years that involves the use and the creation of bio-inspired materials and their technologies for highly selective biosensing, nanoarchitecture engineering and nanoelectronics. Increasing researches have been offered to a fundamental understanding how the interactions between the nanoparticles and DNA molecules could alter DNA molecular structure and its biochemical activities. This minor review describes the mechanisms of the nanoparticle-DNA binding and molecular interactions. We present recent discoveries and research progresses how the nanoparticle-DNA binding could vary DNA molecular structure, DNA detection, and gene therapy. We report a few case studies associated with the application of the nanoparticle-DNA binding devices in medical detection and biotechnology. The potential impacts of the nanoparticles via DNA binding on toxicity of the microorganisms are briefly discussed. The nanoparticle-DNA interactions and their impact on molecular and microbial functionalities have only drown attention in recent a few years. The information presented in this review can provide useful references for further studies on biomedical science and technology. |
Keywords: | DNA binding DNA structure Nanoparticles Molecular interactions Cytotoxity |
Rights: | © 2012 Elsevier Inc. All rights reserved. |
DOI: | 10.1016/j.biotechadv.2012.03.007 |
Published version: | http://dx.doi.org/10.1016/j.biotechadv.2012.03.007 |
Appears in Collections: | Aurora harvest 4 Chemical Engineering publications Environment Institute publications |
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