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https://hdl.handle.net/2440/76710
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Type: | Journal article |
Title: | Association of the dystrobrevin binding protein 1 gene (DTNBP1) in a bipolar case-control study (BACCS) |
Author: | Gaysina, D. Cohen-Woods, S. Chow, P. Martucci, L. Schosser, A. Ball, H. Tozzi, F. Perry, J. Muglia, P. Craig, I. McGuffin, P. Farmer, A. |
Citation: | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2009; 150B(6):836-844 |
Publisher: | Wiley-Liss |
Issue Date: | 2009 |
ISSN: | 1552-4841 1552-485X |
Statement of Responsibility: | Darya Gaysina, Sarah Cohen-Woods, Philip C. Chow, Livia Martucci, Alexandra Schosser, Harriet A. Ball, Federica Tozzi, Julia Perry, Pierandrea Muglia, Ian W. Craig, Peter McGuffin, and Anne Farmer |
Abstract: | Recent studies suggest a degree of overlap in genetic susceptibility across the traditional categories of schizophrenia and bipolar disorder. There is some evidence for an association of the dystrobrevin binding protein 1 gene (DTNBP1) with schizophrenia, and, thus, this gene has also become a focus of further investigation in bipolar disorder (BD). The aim of our study is to explore the association of DTNBP1 with BD and with a sub phenotype, presence/absence of psychotic symptoms, in a sample of 515 patients with BD (ICD10/DSMIV) and 1,316 ethnically matched control subjects recruited from the UK. Seven DTNBP1 SNPs: rs2743852 (SNP C), rs760761 (P1320), rs1011313 (P1325), rs3213207 (P1635), rs2619539 (P1655), rs16876571 and rs17470454 were investigated using the SNPlex genotyping system and 1 SNP (rs2619522) genotypes were imputed. Association analyses were conducted in a sample of 452 cases and 956 controls. We found significant differences in genotypic and allelic frequencies of rs3213207 and rs760761 of DTNBP1 between bipolar patients and controls. We also showed a global haplotypic association and an association of a particular haplotype with BD. Our results are consistent with previous studies in term of a general association between DTNBP1 and bipolar disorder and provide additional evidence that a portion of the genotypic overlap between schizophrenia and bipolar affective disorder is attributable to this gene. |
Keywords: | dysbindin affective disorder association psychosis haplotype |
Rights: | Copyright © 2008 Wiley-Liss, Inc. |
DOI: | 10.1002/ajmg.b.30906 |
Published version: | http://dx.doi.org/10.1002/ajmg.b.30906 |
Appears in Collections: | Aurora harvest 4 Psychiatry publications |
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