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https://hdl.handle.net/2440/7703
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Type: | Journal article |
Title: | Immune response to enzyme replacement therapy: single epitope control of antigen distribution from circulation |
Author: | Glaros, E. Turner, C. Parkinson, E. Hopwood, J. Brooks, D. |
Citation: | Molecular Genetics and Metabolism, 2002; 77(1-2):127-135 |
Publisher: | Academic Press Inc Elsevier Science |
Issue Date: | 2002 |
ISSN: | 1096-7192 1096-7206 |
Statement of Responsibility: | Glaros, Elias N ; Turner, Chris T ; Parkinson, Emma J ; Hopwood, John J ; Brooks, Doug A |
Abstract: | Immune response to replacement therapy has been reported for a range of therapeutic strategies being developed for the treatment of patients with genetic disease. The potential problem of immune response to enzyme replacement therapy has been investigated in alpha-L-iduronidase immunized rats, representing a model of the lysosomal storage disorder Hurler syndrome (alpha-L-iduronidase deficiency). The antibody response to alpha-L-iduronidase showed that the positional location of antibody reactivity was similar for different immunized rats, but the precise linear sequence epitopes identified, varied between rats. A monoclonal antibody reacting to an epitope in close proximity to one high antigenicity site on alpha-L-iduronidase was used to reproduce the in vivo effect of altered enzyme tissue distribution, previously observed in immunized rats infused with alpha-L-iduronidase. The study demonstrated that during an immune response, antibody reacting to a single epitope could partially control the tissue distribution of antigen from circulation. |
Keywords: | Lysosomes Animals Humans Mice Rats Rats, Sprague-Dawley Mucopolysaccharidosis I Disease Models, Animal Iduronidase Antibodies, Monoclonal Epitopes Immunization Epitope Mapping Amino Acid Sequence Tissue Distribution Molecular Sequence Data |
DOI: | 10.1016/S1096-7192(02)00148-8 |
Published version: | http://dx.doi.org/10.1016/s1096-7192(02)00148-8 |
Appears in Collections: | Aurora harvest 4 Paediatrics publications |
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